ArticleBMC infectious diseases2019
Clinical characteristics and treatment outcomes in a cohort of patients with pyogenic and amoebic liver abscess.
Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Clinical characteristics, diagnosis, treatment, and outcome of patients with liver abscess due to Aspergillus spp: a systematic review of published cases.BMC infectious diseases · 2024Pooled it
- Epidemiology, pathology, diagnosis, and management of amoebic liver abscesses in Sub-Saharan Africa: a retrospective cross-sectional study.Annals of medicine and surgery (2012) · 2026Article
- Exploration of Various Diagnostic Modalities for Detection of Amoebic Liver Abscess and Co-Occurrence of Other Infective Aetiology, Eastern India.Tropical medicine & international health : TM & IH · 2026Observational
- <p>Molecular medicine reports · 2026Review
- Liver abscesses in Southern Europe: clinical and microbiological characterization of a retrospective cohort.BMC infectious diseases · 2026Observational
- [Clinical characteristics and risk factors of pyogenic liver abscess complicated by sepsis in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Massive Sequencing of V3-V4 Hypervariable Region in Pyogenic Liver Abscesses Reveals the Presence of Unusual Bacteria Not Detected by Classical Culture Methods.Microorganisms · 2025Article
- InvasiveInternational medical case reports journal · 2025Article
- Clinical characteristics and outcomes of liver abscesses: a 12-year retrospective analysis from a tertiary care center in the United Arab Emirates.Frontiers in medicine · 2025Article
- Evaluation of Molecular Assays for Diagnosis of Amoebic Liver Abscess in India with Bayesian Latent Class Analysis.The American journal of tropical medicine and hygiene · 2024Article
- Clinical characteristics and management of liver abscess in The Gambia, a resource-limited country.BMC gastroenterology · 2024Article
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- Multifocal hepatic abscess post-ERCP.BMJ case reports · 2023Article
- Amebic liver abscess byWorld journal of clinical cases · 2022Review
- Therapy of pyogenic liver abscess with a primarily unknown cause.Langenbeck's archives of surgery · 2022Article
- Amebic liver abscess: Clinico-radiological findings and interventional management.World journal of radiology · 2022Review
- Detection ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- A Multicenter Retrospective Study on Clinical Characteristics and Outcome of Pyogenic Liver Abscess Focusing Multidrug-Resistant Organisms.Journal of clinical medicine · 2022Article
- Pleural Empyema as a Complication of Pyogenic Liver Abscess: Can the Minimum Achieve the Optimal? A Comparison of 3 Approaches.The American journal of case reports · 2021Article
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7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe describe the clinical features of a cohort of patients with liver abscesses and investigate relationships between clinical, radiological and microbiological findings and mortality.
methodsRetrospective review of pyogenic (PLA) or amoebic liver abscesses (ALA) diagnosed and treated at a major infectious diseases department in London over 9 years.
resultsOne hundred forty-one patient records were identified; 132 (93.6%) had PLA and 9 (6.4%) ALA. No organism was identified in 38.6% (51/132); a single bacterial species was isolated in 47.0% (62/132) of PLA, ≥ 2 in 14.4% (19/132). There was weak evidence of variation in abscess size by type of microorganism, with streptococcal PLA typically larger (p = 0.03 for Streptococcus milleri group, p = 0.05 for non-milleri streptococci). Patients with ALA were younger (median 41, IQR 37-51 years) than those with PLA (median 68, IQR 50.5-78 years) (p = 0.003) and all were male (9/9, 100%, (p = 0.03)), with a history of recent travel in the majority (6/9, 66.7% (p = 0.003)). C-reactive protein was higher in ALA than in PLA (p = 0.06). In the entire cohort, loculation (HR = 2.51 (95% CI 1.00-6.32), p = 0.04) and baseline ALP (HR = 4.78 (95% CI 1.19-19.2) per log
conclusionsClinical or radiological features cannot be used to distinguish between PLA and ALA, or help identify the bacterial cause of PLA. However, ALA is more common in young, male patients with a history of travel. 16S rRNA analysis of abscess fluid has a role in improving microbiological diagnosis in culture-negative cases.
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