Evidence map›Paper›PMID 31159742›Full record

ArticleBMC bioinformatics2019

ANDIS: an atomic angle- and distance-dependent statistical potential for protein structure quality assessment.

Zhongwang Yu, Yuangen Yao, Haiyou Deng, Ming Yi

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Article in BMC bioinformatics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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6citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  4. An information gain-based approach for evaluating protein structure models.Computational and structural biotechnology journal · 2020
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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Zhongwang YuDepartment of Physics, College of Science, Huazhong Agricultural University, Wuhan, 430070, China.
Yuangen YaoDepartment of Physics, College of Science, Huazhong Agricultural University, Wuhan, 430070, China.
Haiyou DengDepartment of Physics, College of Science, Huazhong Agricultural University, Wuhan, 430070, China. hydeng@mail.hzau.edu.cn.ORCID http://orcid.org/0000-0002-0069-0510
Ming YiDepartment of Physics, College of Science, Huazhong Agricultural University, Wuhan, 430070, China. yiming@mail.hzau.edu.cn.

Funding

Huazhong Agricultural University Scientific and Technological Self-innovation Foundation Program 2015RC021National Natural Science Foundation of China 11604111National Natural Science Foundation of China 11675060National Natural Science Foundation of China 91730301the fundamental Research Funds for the Central-Universities 2662018JC017
6 · The paper itself

Abstract

backgroundThe knowledge-based statistical potential has been widely used in protein structure modeling and model quality assessment. They are commonly evaluated based on their abilities of native recognition as well as decoy discrimination. However, these two aspects are found to be mutually exclusive in many statistical potentials.

resultsWe developed an atomic ANgle- and DIStance-dependent (ANDIS) statistical potential for protein structure quality assessment with distance cutoff being a tunable parameter. When distance cutoff is ≤9.0 Å, "effective atomic interaction" is employed to enhance the ability of native recognition. For a distance cutoff of ≥10 Å, the distance-dependent atom-pair potential with random-walk reference state is combined to strengthen the ability of decoy discrimination. Benchmark tests on 632 structural decoy sets from diverse sources demonstrate that ANDIS outperforms other state-of-the-art potentials in both native recognition and decoy discrimination.

conclusionsDistance cutoff is a crucial parameter for distance-dependent statistical potentials. A lower distance cutoff is better for native recognition, while a higher one is favorable for decoy discrimination. The ANDIS potential is freely available as a standalone application at http://qbp.hzau.edu.cn/ANDIS/ .

Indexed as

SoftwareStatistics as TopicComputational BiologyDatabases, ProteinProtein ConformationProtein FoldingProteinsProteinsDistance cutoffPair-wise interactionProtein decoy setProtein structure predictionStatistical potential

Identifiers

PMID31159742
PMCPMC6547486

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