Evidence map›Paper›PMID 31159739›Full record

Trial reportBMC anesthesiology2019

Effect of ultrafiltration on extravascular lung water assessed by lung ultrasound in children undergoing cardiac surgery: a randomized prospective study.

Mohamed Elayashy, Mai A Madkour, Ahmed Abdelaal Ahmed Mahmoud, Hisham Hosny, Amr Hussein, Ahmed Nabih, Ahmed Lofty, Hamza Mohamed Hamza, Passaint Hassan, Mohamed Wagih and 1 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03146143 (Effect of Ultra Filtration on Extravascular Lung Water Assessed by Lung Ultrasound in Pediatric Cardiac Surgery), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03146143 nacompletednot on this map

Effect of Ultra Filtration on Extravascular Lung Water Assessed by Lung Ultrasound in Pediatric Cardiac Surgery

TypeinterventionalSponsorKasr El Aini HospitalRan2017 to 2017Enrolled60ConditionsCongenital Cardiac DisordersArmsultrafiltration
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Effects of Erythropoietin on Lung Injury Induced by Cardiopulmonary Bypass After Cardiac Surgery.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Trial
  2. The Utility of Lung Ultrasound Scoring in Predicting Post-Extubation Respiratory Support After Congenital Heart Surgery.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Observational
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Mohamed ElayashyDepartment of Anesthesia and Intensive Care, Kasr Al Ainy Faculty of Medicine, Cairo University, 7 Elshishiny St., El Maryotia, Faysal, Giza, 12131, Egypt. mohamedelayashy@kasralainy.edu.eg.ORCID 0000-0002-6539-8123
Mai A MadkourDepartment of Anesthesia and Intensive Care, Kasr Al Ainy Faculty of Medicine, Cairo University, 7 Elshishiny St., El Maryotia, Faysal, Giza, 12131, Egypt.
Ahmed Abdelaal Ahmed MahmoudDepartment of Anesthesia, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Hisham HosnyDepartment of Anesthesia and Intensive Care, Kasr Al Ainy Faculty of Medicine, Cairo University, 7 Elshishiny St., El Maryotia, Faysal, Giza, 12131, Egypt.
Amr HusseinDepartment of Anesthesia and Intensive Care, Kasr Al Ainy Faculty of Medicine, Cairo University, 7 Elshishiny St., El Maryotia, Faysal, Giza, 12131, Egypt.
Ahmed NabihDepartment of Anesthesia and Intensive Care, Kasr Al Ainy Faculty of Medicine, Cairo University, 7 Elshishiny St., El Maryotia, Faysal, Giza, 12131, Egypt.
Ahmed LoftyDepartment of Anesthesia and Intensive Care, Kasr Al Ainy Faculty of Medicine, Cairo University, 7 Elshishiny St., El Maryotia, Faysal, Giza, 12131, Egypt.
Hamza Mohamed HamzaDepartment of Anesthesia and Intensive Care, Kasr Al Ainy Faculty of Medicine, Cairo University, 7 Elshishiny St., El Maryotia, Faysal, Giza, 12131, Egypt.
Passaint HassanDepartment of Anesthesia and Intensive Care, Kasr Al Ainy Faculty of Medicine, Cairo University, 7 Elshishiny St., El Maryotia, Faysal, Giza, 12131, Egypt.
Mohamed WagihDepartment of Anesthesia and Intensive Care, Kasr Al Ainy Faculty of Medicine, Cairo University, 7 Elshishiny St., El Maryotia, Faysal, Giza, 12131, Egypt.
Ahmed Kareem MohamedDepartment of Anesthesia and Intensive Care, Kasr Al Ainy Faculty of Medicine, Cairo University, 7 Elshishiny St., El Maryotia, Faysal, Giza, 12131, Egypt.
Cairo University · EGBeni-Suef University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreased lung water and the resultant atelectasis are significant pulmonary complications after cardiopulmonary bypass (CPB) in children undergoing cardiac surgery; these complications are observed after CPB than after anaesthesia alone. Ultrafiltration has been shown to decrease total body water and postoperative blood loss and improve the alveolar to arterial oxygen gradient and pulmonary compliance. This study investigated whether conventional ultrafiltration during CPB in paediatric heart surgeries influences post-bypass extravascular lung water (EVLW) assessed by lung ultrasound (LUS).

methodsThis randomized controlled study included 60 patients with congenital heart disease (ASA II-III), aged 1 to 48 months, with a body weight > 3 kg. Conventional ultrafiltration targeting a haematocrit (HCT) level of 28% was performed on the ultrafiltration group, while the control group did not receive ultrafiltration. LUS scores were recorded at baseline and at the end of surgery. The PaO2/FiO2 ratio (arterial oxygen tension divided by the fraction of inspired oxygen), urine output, and haemodynamic parameters were also recorded.

resultsLUS scores were comparable between the two groups both at baseline (p = 0.92) and at the end of surgery (p = 0.95); however, within the same group, the scores at the end of surgery significantly differed from their baseline values in both the ultrafiltration (p = 0.01) and non-ultrafiltration groups (p = 0.02). The baseline PaO2/FiO2 ratio was comparable between both groups. at the end of surgery, The PaO2/FiO2 ratio increased in the ultrafiltration group compared to that in the non-ultrafiltration group, albeit insignificant (p = 0.16). no correlation between the PaO2/FiO2 ratio and LUS score was found at baseline (r = - 0.21, p = 0.31). On the other hand, post-surgical measurements were negatively correlated (r = - 0.41, p = 0.045).

conclusionConventional ultrafiltration did not alter the EVLW when assessed by LUS and oxygenation state. Similarly, ultrafiltration did not affect the urea and creatinine levels, intensive care unit (ICU) stays, ventilation days, or mortality.

trial registrationClinicaltrials.gov Identifier: NCT03146143 registered on 29-April-2017.

Indexed as

Cardiac Surgical ProceduresCardiopulmonary BypassChild, PreschoolExtravascular Lung WaterFemaleFollow-Up StudiesHumansInfantLungMaleProspective StudiesUltrafiltrationUltrasonography, InterventionalExtravascular lung waterLung ultrasoundPaediatric cardiac surgeryUltrafiltration

Identifiers

PMID31159739
PMCPMC6547534
OpenAlexW2948339364

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.