Evidence map›Paper›PMID 31159508›Full record

ArticlePolymers2019

Preparation of PolyHIPE Scaffolds for 3D Cell Culture and the Application in Cytotoxicity Evaluation of Cigarette Smoke.

Peijian Sun, Song Yang, Xuehui Sun, Yipeng Wang, Yunzhen Jia, Pingping Shang, Haiying Tian, Guozheng Li, Ruyang Li, Xiaobing Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Peijian SunKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC, No.2 Fengyang Street, Zhengzhou 450001, China. pjsunztri@163.com.
Song YangKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC, No.2 Fengyang Street, Zhengzhou 450001, China. yangsong@mail.ustc.edu.cn.
Xuehui SunKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC, No.2 Fengyang Street, Zhengzhou 450001, China. xuehui_sun1234@aliyun.com.
Yipeng WangKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC, No.2 Fengyang Street, Zhengzhou 450001, China. yipeng_w@sina.com.
Yunzhen JiaKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC, No.2 Fengyang Street, Zhengzhou 450001, China. xiaojia2003@163.com.
Pingping ShangKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC, No.2 Fengyang Street, Zhengzhou 450001, China. shangpingpingan@126.com.
Haiying TianTechnology Center, China Tobacco Henan Industrial Co., Ltd., Zhengzhou 450000, China. haiyingflying@163.com.
Guozheng LiTechnology Center, China Tobacco Henan Industrial Co., Ltd., Zhengzhou 450000, China. guozheng_li@126.com.
Ruyang LiKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC, No.2 Fengyang Street, Zhengzhou 450001, China. liruyang1992@163.com.
Xiaobing ZhangKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC, No.2 Fengyang Street, Zhengzhou 450001, China. zhangxiaobing985@sohu.com.
Cong NieKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC, No.2 Fengyang Street, Zhengzhou 450001, China. niec@ztri.com.cn.

Funding

the Dean Science and Technology Development Foundation of Zhengzhou Tobacco Research Institute 332016CA0210
6 · The paper itself

Abstract

Polystyrene-based polyHIPE (polymerized high internal phase emulsion) materials were prepared by the copolymerization of styrene and divinylbenzene in the continuous phase of a HIPE. The resultant polyHIPE materials were found to have an open-cellular morphology and high porosity, and the polyHIPE structure could be well adjusted by varying the water/oil (W/O) ratio and the amount of emulsifier in the HIPE. Cell culture results showed that the resultant polyHIPE materials, which exhibited larger voids and connected windows as well as high porosity, could promote cell proliferation on the 3D scaffold. A 3D cell cytotoxicity evaluation system was constructed with the polystyrene-based polyHIPE materials as scaffolds and the cigarette smoke cytotoxicity was evaluated. Results showed that the smoke cytotoxicity against A549 cells is much lower in the 3D cell platform compared to the traditional 2D system, showing the great potential of the polyHIPE scaffolds for 3D cell culture and the cytotoxic evaluation of cigarette smoke.

Indexed as

3D cell culturecigarette smokecytotoxicity evaluationpolyHIPEpolystyrene

Identifiers

PMID31159508
PMCPMC6631592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.