Evidence map›Paper›PMID 31159465›Full record

ArticleInternational journal of molecular sciences2019

Enhanced Protection of Biological Membranes during Lipid Peroxidation: Study of the Interactions between Flavonoid Loaded Mesoporous Silica Nanoparticles and Model Cell Membranes.

Lucija Mandić, Anja Sadžak, Vida Strasser, Goran Baranović, Darija Domazet Jurašin, Maja Dutour Sikirić, Suzana Šegota

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lucija MandićRuđer Bošković Institute, Division of Physical Chemistry, 10000 Zagreb, Croatia. Lucija.Mandic@irb.hr.
Anja SadžakRuđer Bošković Institute, Division of Physical Chemistry, 10000 Zagreb, Croatia. Anja.Sadzak@irb.hr.
Vida StrasserRuđer Bošković Institute, Division of Physical Chemistry, 10000 Zagreb, Croatia. Vida.Cadez@irb.hr.
Goran BaranovićRuđer Bošković Institute, Division of Organic Chemistry and Biochemistry, 10000 Zagreb, Croatia. Goran.Baranovic@irb.hr.
Darija Domazet JurašinRuđer Bošković Institute, Division of Physical Chemistry, 10000 Zagreb, Croatia. Darija.Jurasin@irb.hr.
Maja Dutour SikirićRuđer Bošković Institute, Division of Physical Chemistry, 10000 Zagreb, Croatia. sikiric@irb.hr.
Suzana ŠegotaRuđer Bošković Institute, Division of Physical Chemistry, 10000 Zagreb, Croatia. ssegota@irb.hr.
Ruđer Bošković Institute · HR

Funding

Croatian Agency for SMEs, Innovations and Investments PoC6_11_46.Hrvatska Zaklada za Znanost IP-2016-06-8415
6 · The paper itself

Abstract

Flavonoids, polyphenols with anti-oxidative activity have high potential as novel therapeutics for neurodegenerative disease, but their applicability is rendered by their poor water solubility and chemical instability under physiological conditions. In this study, this is overcome by delivering flavonoids to model cell membranes (unsaturated DOPC) using prepared and characterized biodegradable mesoporous silica nanoparticles, MSNs. Quercetin, myricetin and myricitrin have been investigated in order to determine the relationship between flavonoid structure and protective activity towards oxidative stress, i.e., lipid peroxidation induced by the addition of hydrogen peroxide and/or Cu

Indexed as

Lipid PeroxidationModels, BiologicalCell MembraneDrug LiberationElastic ModulusFlavonoidsHumansLiposomesMicroscopy, Atomic ForceNanoparticlesOxidation-ReductionSilicon DioxideSpectrum AnalysisFlavonoidsLiposomesSilicon Dioxidelipid peroxidationmembrane elasticitymesoporous silica nanoparticlesmyricetinmyricitrinnanomechanicsprotective effects of flavonoidsquercetin

Identifiers

PMID31159465
PMCPMC6600359
OpenAlexW2937272492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.