ReviewJournal of clinical medicine2019
MaioRegen Osteochondral Substitute for the Treatment of Knee Defects: A Systematic Review of the Literature.
Review in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- The MOBCART (magnetic resonance observation of bone and cartilage repair tissue) add-on score.Insights into imaging · 2026Article
- Surgical Technique for Treating Focal Osteochondral Knee Lesions Using an Aragonite-Based Biphasic Scaffold.Arthroscopy techniques · 2026Article
- Natural Biomaterials for Osteochondral Repair: From Source to Strategy.Advanced healthcare materials · 2026Review
- Visualized Trends and Bibliometric Analysis in 3D Printing for Osteochondral Repair: A Comprehensive Research Study from 2010 to 2024.3D printing and additive manufacturing · 2026Article
- Recombinant Human Amelogenin Protein Enhances Healing of Osteochondral Injury in a Goat Model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Synovial Fluid and Serum Inflammation Biomarkers After Autologous Matrix-Induced Chondrogenesis (AMIC) for Knee Chondral Defects.Journal of clinical medicine · 2026Article
- The osteochondral regeneration paradox: why biomimetic scaffolds are biologically superior but injectable systems dominate the clinic.RSC advances · 2026Review
- Prognostic Role of Lesion Morphology in Patellar Osteochondral Fixation: Influence of Localization and Size on Functional and Pain Outcomes.Journal of clinical medicine · 2025Article
- Biomimetic tri-layered osteochondral scaffold : study of early implant stability in a sheep model.Bone & joint research · 2025Article
- Report on Evolving Indications, Techniques, and Outcome of Novel and Innovative Surgical procedure - Agili C®.Current reviews in musculoskeletal medicine · 2025Review
- Arthroscopic Implantation of a Cell-Free Bilayer Scaffold for the Treatment of Knee Chondral Lesions: A 2-Year Prospective Study.Cartilage · 2025Article
- Osteochondral solutions for cartilage lesions of the knee: a narrative review.Annals of joint · 2025Review
- Acellular Aragonite-Based Scaffold for the Treatment of Joint Surface Lesions of the Knee: A Minimum 5-Year Follow-Up Study.Cartilage · 2024Article
- Functional performance of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold: a pre-clinicalRoyal Society open science · 2024Article
- Multiphasic scaffolds for the repair of osteochondral defects: Outcomes of preclinical studies.Bioactive materials · 2023Review
- Role of Doxycycline as an Osteoarthritis Disease-Modifying Drug.Journal of clinical medicine · 2023Article
- Progress and prospect of technical and regulatory challenges on tissue-engineered cartilage as therapeutic combination product.Bioactive materials · 2023Review
- Promoting endogenous articular cartilage regeneration using extracellular matrix scaffolds.Materials today. Bio · 2022Article
- Articular cartilage delamination at eight years following cellular-based repair procedures: a case reports.Journal of experimental orthopaedics · 2022Article
- The treatment of knee cartilage lesions: state of the art.Acta bio-medica : Atenei Parmensis · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aims to investigate the clinical and radiological efficacy of three-dimensional acellular scaffolds (MaioRegen) in restoring osteochondral knee defects.
methodsMEDLINE, Scopus, CINAHL, Embase, and Cochrane Databases were searched for articles in which patients were treated with MaioRegen for osteochondral knee defects.
resultsA total of 471 patients were included in the study (mean age 34.07 ± 5.28 years). The treatment involved 500 lesions divided as follows: 202 (40.4%) medial femoral condyles, 107 (21.4%) lateral femoral condyles, 28 (5.6%) tibial plateaus, 46 (9.2%) trochleas, 74 (14.8%) patellas, and 43 (8.6%) unspecified femoral condyles. Mean lesion size was 3.6 ± 0.85 cm
conclusionThis systematic review describes the current available evidence for the treatment of osteochondral knee defects with MaioRegen Osteochondral substitute reporting promising satisfactory and reliable results at mid-term follow-up. A low rate of complications and failure was reported, confirming the safety of this scaffold. Considering the low level of evidence of the study included in the review, this data does not support the superiority of the Maioregen in terms of clinical improvement at follow-up compared to conservative treatment or other cartilage techniques.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.