Evidence map›Paper›PMID 31159334›Full record

ArticleSensors (Basel, Switzerland)2019

A Mechatronic Platform for Computer Aided Detection of Nodules in Anatomopathological Analyses via Stiffness and Ultrasound Measurements.

Luca Massari, Andrea Bulletti, Sahana Prasanna, Marina Mazzoni, Francesco Frosini, Elena Vicari, Marcello Pantano, Fabio Staderini, Gastone Ciuti, Fabio Cianchi and 4 more

Open access · goldAbstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Smart Sensors for Healthcare and Medical Applications.Sensors (Basel, Switzerland) · 2021
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Luca MassariSant'Anna School of Advanced Studies, The BioRobotics Institute, 56025 Pisa, Italy. luca.massari@santannapisa.it.
Andrea BullettiDepartment of Information Engineering, Università Degli Studi di Firenze, 50121 Florence, Italy. andrea.bulletti@unifi.it.
Sahana PrasannaSant'Anna School of Advanced Studies, The BioRobotics Institute, 56025 Pisa, Italy. sahana.prasanna@santannapisa.it.
Marina MazzoniDepartment of Information Engineering, Università Degli Studi di Firenze, 50121 Florence, Italy. m.mazzoni@ifac.cnr.it.
Francesco FrosiniAzienda Ospedaliera Careggi University Hospital of Florence and University of Florence, 50134 Florence, Italy. francesco.frosini@unifi.it.
Elena VicariSant'Anna School of Advanced Studies, The BioRobotics Institute, 56025 Pisa, Italy. elenavicari.ev@gmail.com.
Marcello PantanoSant'Anna School of Advanced Studies, The BioRobotics Institute, 56025 Pisa, Italy. marcello.pantano03@gmail.com.
Fabio StaderiniAzienda Ospedaliera Careggi University Hospital of Florence and University of Florence, 50134 Florence, Italy. staderini.fabio@gmail.com.
Gastone CiutiSant'Anna School of Advanced Studies, The BioRobotics Institute, 56025 Pisa, Italy. gastone.ciuti@santannapisa.it.
Fabio CianchiAzienda Ospedaliera Careggi University Hospital of Florence and University of Florence, 50134 Florence, Italy. fabio.cianchi@unifi.it.
Luca MesseriniAzienda Ospedaliera Careggi University Hospital of Florence and University of Florence, 50134 Florence, Italy. luca.messerini@unifi.it.
Lorenzo CapineriDepartment of Information Engineering, Università Degli Studi di Firenze, 50121 Florence, Italy. lorenzo.capineri@unifi.it.
Arianna MenciassiSant'Anna School of Advanced Studies, The BioRobotics Institute, 56025 Pisa, Italy. arianna.menciassi@santannapisa.it.
Calogero Maria OddoSant'Anna School of Advanced Studies, The BioRobotics Institute, 56025 Pisa, Italy. calogero.oddo@santannapisa.it.
Scuola Superiore Sant'Anna · ITAzienda Ospedaliero-Universitaria Careggi · ITUniversity of Florence · ITNello Carrara Institute of Applied Physics · IT

Funding

Regione Toscana CUPD66D16000120002
6 · The paper itself

Abstract

This study presents a platform for ex-vivo detection of cancer nodules, addressing automation of medical diagnoses in surgery and associated histological analyses. The proposed approach takes advantage of the property of cancer to alter the mechanical and acoustical properties of tissues, because of changes in stiffness and density. A force sensor and an ultrasound probe were combined to detect such alterations during force-regulated indentations. To explore the specimens, regardless of their orientation and shape, a scanned area of the test sample was defined using shape recognition applying optical background subtraction to the images captured by a camera. The motorized platform was validated using seven phantom tissues, simulating the mechanical and acoustical properties of ex-vivo diseased tissues, including stiffer nodules that can be encountered in pathological conditions during histological analyses. Results demonstrated the platform's ability to automatically explore and identify the inclusions in the phantom. Overall, the system was able to correctly identify up to 90.3% of the inclusions by means of stiffness in combination with ultrasound measurements, paving pathways towards robotic palpation during intraoperative examinations.

Indexed as

RoboticsAnimalsHumansNeoplasmsUltrasonographyautomatic robotic platformcancer nodules detectionphantomremote support for pathologistsstiffness analysisultrasound analysisvisual analysis

Identifiers

PMID31159334
PMCPMC6603638
OpenAlexW2930709637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.