Evidence map›Paper›PMID 31159273›Full record

ArticleBiomolecules2019

Distant Non-Obvious Mutations Influence the Activity of a Hyperthermophilic

Kalyanasundaram Subramanian, Karolina Mitusińska, John Raedts, Feras Almourfi, Henk-Jan Joosten, Sjon Hendriks, Svetlana E Sedelnikova, Servé W M Kengen, Wilfred R Hagen, Artur Góra and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Applications of water molecules for analysis of macromolecule properties.Computational and structural biotechnology journal · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 4 countries.

Kalyanasundaram SubramanianLaboratory of Systems and Synthetic Biology, Wageningen University, Stippeneng 4, 6708 WE Wageningen, The Netherlands. kal.sundar@gmail.com.
Karolina MitusińskaBiotechnology Center, Silesian University of Technology, ul. Krzywoustego 8, 44-100 Gliwice, Poland. k.mitusinska@tunnelinggroup.pl.ORCID 0000-0002-0183-0845
John RaedtsLaboratory of Microbiology, Wageningen University, Stippeneng 4, 6708 WE Wageningen, The Netherlands. johnraedts@hotmail.com.
Feras AlmourfiSaudi Human Genome Project, National Center of Genome Technology, King Abdulaziz City for Science and Technology (KACST), Riyadh 11442, Saudi Arabia. almourfif@gmail.com.
Henk-Jan JoostenBio-Prodict, Nieuwe Marktstraat 54E, 6511 AA Nijmegen, The Netherlands. joosten@bio-prodict.nl.
Sjon HendriksLaboratory of Microbiology, Wageningen University, Stippeneng 4, 6708 WE Wageningen, The Netherlands. sjon.hendriks@wur.nl.
Svetlana E SedelnikovaThe Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK. s.e.sedelnikova@sheffield.ac.uk.
Servé W M KengenLaboratory of Microbiology, Wageningen University, Stippeneng 4, 6708 WE Wageningen, The Netherlands. serve.kengen@wur.nl.
Wilfred R HagenDepartment of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands. w.r.hagen@tudelft.nl.
Artur GóraBiotechnology Center, Silesian University of Technology, ul. Krzywoustego 8, 44-100 Gliwice, Poland. a.gora@tunnelinggroup.pl.ORCID 0000-0003-2530-6957
Vitor A P Martins Dos SantosLaboratory of Systems and Synthetic Biology, Wageningen University, Stippeneng 4, 6708 WE Wageningen, The Netherlands. vitor.martinsdossantos@wur.nl.
Patrick J BakerThe Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK. p.baker@sheffield.ac.uk.ORCID 0000-0003-1995-5643
John van der OostLaboratory of Microbiology, Wageningen University, Stippeneng 4, 6708 WE Wageningen, The Netherlands. John.vanderOost@wur.nl.
Peter J SchaapLaboratory of Systems and Synthetic Biology, Wageningen University, Stippeneng 4, 6708 WE Wageningen, The Netherlands. peter.schaap@wur.nl.ORCID 0000-0002-4346-6084
Wageningen University & Research · NLSilesian University of Technology · PLUniversity of Sheffield · GBBio-Prodict (Netherlands) · NLDelft University of Technology · NLKing Abdulaziz City for Science and Technology · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cupin-type phosphoglucose isomerase (PfPGI) from the hyperthermophilic archaeon

Indexed as

MutationTemperatureEnzyme InhibitorsGlucose-6-Phosphate IsomeraseManganeseMolecular Dynamics SimulationMutant ProteinsProtein ConformationProtein EngineeringPyrococcus furiosusWaterEnzyme InhibitorsGlucose-6-Phosphate IsomeraseManganeseMutant ProteinsWaterComulatorcupin phosphoglucose isomeraseProtein engineeringPyrococcus furiosussolvent access

Identifiers

PMID31159273
PMCPMC6627849
OpenAlexW2947709207

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.