Evidence map›Paper›PMID 31159244›Full record

ArticleBioengineering (Basel, Switzerland)2019

A Microcavity Array-Based 4D Cell Culture Platform.

Cordula Nies, Tobias Rubner, Hanna Lorig, Vera Colditz, Helen Seelmann, Andreas Müller, Eric Gottwald

Open access · goldAbstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. OFrontiers in bioengineering and biotechnology · 2023
    Article
  2. Highlights on Advancing Frontiers in Tissue Engineering.Tissue engineering. Part B, Reviews · 2022
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Cordula NiesKarlsruhe Institute of Technology, Institute of Functional Interfaces, Hermann-von-Helmholtz-P1atz 1, 76344 Eggenstein-Leopoldshafen, Germany. cordula.nies@kit.edu.
Tobias RubnerDeutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. t.rubner@dkfz-heidelberg.de.
Hanna LorigKarlsruhe Institute of Technology, Institute of Functional Interfaces, Hermann-von-Helmholtz-P1atz 1, 76344 Eggenstein-Leopoldshafen, Germany. mail@hanna-lorig.de.
Vera ColditzBayer AG, Dept. Engineering and Technology, Kaiser-Wilhelm-Allee 3, 51373 Leverkusen, Germany. vera.colditz@outlook.com.
Helen SeelmannRoche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg, Germany. helense@gmx.de.
Andreas MüllerStädtisches Klinikum Karlsruhe, Frauenklinik, Moltkestr. 90, 76133 Karlsruhe, Germany. andreas.mueller.fk@klinikum-karlsruhe.de.
Eric GottwaldKarlsruhe Institute of Technology, Institute of Functional Interfaces, Hermann-von-Helmholtz-P1atz 1, 76344 Eggenstein-Leopoldshafen, Germany. eric.gottwald@kit.edu.
Karlsruhe Institute of Technology · DEBayer (Germany) · DEDKFZ-ZMBH Alliance · DERoche Pharma AG (Germany) · DEStädtisches Klinikum Karlsruhe · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: We describe a 4D cell culture platform with which we tried to detect and to characterize migration dynamics of single hematopoietic stem cells in polymer film microcavity arrays integrated into a microtiter plate. (2) Methods: The system was set up with CD34-expressing KG-1a cells as a surrogate for hematopoietic stem cells. We then evaluated the system as an artificial hematopoietic stem cell niche model comprised of a co-culture of human hematopoietic stem cells from cord blood (cord blood CD34

Indexed as

3D cell culture4D microscopy platformco-culturehematopoietic progenitor cellsmesenchymal stromal cellsmicrocavity array

Identifiers

PMID31159244
PMCPMC6631836
OpenAlexW2947878019

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.