Evidence map›Paper›PMID 31159186›Full record

ReviewAntioxidants (Basel, Switzerland)2019

Dietary Polyphenol Intake, Blood Pressure, and Hypertension: A Systematic Review and Meta-Analysis of Observational Studies.

Justyna Godos, Marilena Vitale, Agnieszka Micek, Sumantra Ray, Daniela Martini, Daniele Del Rio, Gabriele Riccardi, Fabio Galvano, Giuseppe Grosso

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 12 pooled it
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 12 syntheses or guidelines pooled it, 133 citations in OpenAlex.

  1. Pooled it
  2. Impact of a Chokeberry (Nutrients · 2025
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  6. Biomarkers of Berry Intake: Systematic Review Update.Journal of agricultural and food chemistry · 2023
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Justyna GodosDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy. justyna.godos@student.uj.edu.pl.ORCID 0000-0002-5809-5706
Marilena VitaleDepartment of Clinical Medicine and Surgery, "Federico II" University, 80131 Naples, Italy. marilena.vitale@yahoo.it.
Agnieszka MicekDepartment of Nursing Management and Epidemiology Nursing, Faculty of Health Sciences, Jagiellonian University Medical College, 31-501 Krakow, Poland. agnieszka.micek@uj.edu.pl.ORCID 0000-0001-8557-1774
Sumantra RayNNEdPro Global Centre for Nutrition and Health, St John's Innovation Centre, Cambridge CB4 0WS, UK; Wolfson College at the University of Cambridge, Cambridge CB3 9BB, UK; Nutrition Innovation Centre for Food and Health at Ulster University, Coleraine BT52 1SA, UK. s.ray@nnedpro.org.uk.
Daniela MartiniThe Laboratory of Phytochemicals in Physiology, Department of Veterinary Science, University of Parma, 43126 Parma, Italy. daniela.martini@unipr.it.ORCID 0000-0001-8298-926X
Daniele Del RioNNEdPro Global Centre for Nutrition and Health, St John's Innovation Centre, Cambridge CB4 0WS, UK; Wolfson College at the University of Cambridge, Cambridge CB3 9BB, UK; Nutrition Innovation Centre for Food and Health at Ulster University, Coleraine BT52 1SA, UK. daniele.delrio@unipr.it.ORCID 0000-0001-5394-1259
Gabriele RiccardiDepartment of Clinical Medicine and Surgery, "Federico II" University, 80131 Naples, Italy. riccardi@unina.it.
Fabio GalvanoDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy. fgalvano@unict.it.ORCID 0000-0003-0644-0755
Giuseppe GrossoDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy. giuseppe.grosso@studium.unict.it.ORCID 0000-0003-3930-5285
University of Catania · ITFederico II University Hospital · ITUniversity of Parma · ITJagiellonian University · PLUniversity of Ulster · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDietary polyphenols, including flavonoids, have been the focus of major recent attentions due to their wide content in a variety of foods commonly consumed and the findings from numerous studies showing evidence of an association with positive outcomes on human health.

methodsA systematic search using electronic databases PubMed and EMBASE was performed to retrieve English language studies published from the earliest indexing year of each database to April 2019, reporting on the association between dietary flavonoids intake and hypertension.

resultsThe search strategy resulted in the final selection of 20 studies including 15 cross-sectional investigations and 7 prospective cohorts (1 study reported on 3 prospective cohorts). 5 prospective cohorts, comprising 200,256 individuals and 45,732 cases of hypertension were included in the quantitative analysis. Analysis by extreme quantiles of intake of flavonoid showed a non-significant association with decreased risk of hypertension (RR (risk ratio): 0.96, 95% CI (confidence interval): 0.89, 1.03). Taking into consideration individual flavonoid subclasses, dietary anthocyanins intake was associated with 8% reduction in risk of hypertension, when comparing highest vs. lowest exposure (RR: 0.92, 95% CI: 0.88, 0.97).

conclusionsFurther studies are needed to strengthen the retrieved association between anthocyanins consumption and decreased risk of hypertension and clarify whether total flavonoids or rather individual subclasses may exert beneficial effects on blood pressure.

Indexed as

anthocyaninblood pressurecohortflavonesflavonoidhypertensionmeta-analysis

Identifiers

PMID31159186
PMCPMC6616647
OpenAlexW2946974570

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.