ArticleJournal of movement disorders2019
Nonmotor and Dopamine Transporter Change in REM Sleep Behavior Disorder by Olfactory Impairment.
Article in Journal of movement disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Neuropsychological Changes in Isolated REM Sleep Behavior Disorder: A Systematic Review and Meta-analysis of Cross-sectional and Longitudinal Studies.Neuropsychology review · 2024Pooled it
- Longitudinal Trajectory of Multimodal Markers in a Patient with Isolated REM Sleep Behavior Disorder.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Cholinergic basal forebrain degeneration in isolated REM sleep behaviour disorder.Brain : a journal of neurology · 2025Article
- Blood microbiome signatures in the REM sleep behavior disorder-Lewy body disease continuum.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Characterizing Parkinson's Disease Clinical and Biomarker Interactions in REM Sleep Behavior Disorder.medRxiv : the preprint server for health sciences · 2025Article
- Imaging Procedure and Clinical Studies of [Nuclear medicine and molecular imaging · 2024Review
- Brain olfactory-related atrophy in isolated rapid eye movement sleep behavior disorder.Annals of clinical and translational neurology · 2023Article
- Validation of the REM behaviour disorder phenoconversion-related pattern in an independent cohort.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Neurofilament light chain and cardiac MIBG uptake as predictors for phenoconversion in isolated REM sleep behavior disorder.Journal of neurology · 2023Article
- Longitudinal evolution of cortical thickness signature reflecting Lewy body dementia in isolated REM sleep behavior disorder: a prospective cohort study.Translational neurodegeneration · 2023Article
- Odor Identification by Parkinson's Disease Patients Tested by Using Sniffin' Sticks versus Natural Spices.Parkinson's disease · 2022Article
- Longitudinal Changes in Isolated Rapid Eye Movement Sleep Behavior Disorder-Related Metabolic Pattern Expression.Movement disorders : official journal of the Movement Disorder Society · 2021Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveIt is unclear whether the decline in dopamine transporters (DAT) differs among idiopathic rapid eye movement sleep behavior disorder (iRBD) patients with different levels of olfactory impairment. This study aimed to characterize DAT changes in relation to nonmotor features in iRBD patients by olfactory loss.
methodsThis prospective cohort study consisted of three age-matched groups: 30 polysomnography-confirmed iRBD patients, 30 drug-naïve Parkinson's disease patients, and 19 healthy controls without olfactory impairment. The iRBD group was divided into two groups based on olfactory testing results. Participants were evaluated for reported prodromal markers and then underwent 18F-FP-CIT positron emission tomography and 3T MRI. Tracer uptakes were analyzed in the caudate, anterior and posterior putamen, substantia nigra, and raphe nuclei.
resultsOlfactory impairment was defined in 38.5% of iRBD patients. Mild parkinsonian signs and cognitive functions were not different between the two iRBD subgroups; however, additional prodromal features, constipation, and urinary and sexual dysfunctions were found in iRBD patients with olfactory impairment but not in those without. Tracer uptake showed significant group differences in all brain regions, except the raphe nuclei. The iRBD patients with olfactory impairment had uptake reductions in the anterior and posterior putamen, caudate, and substantia nigra (p < 0.016 in all, adjusted for age), which ranged from 0.6 to 0.8 of age-normative values. In contrast, those without olfactory impairment had insignificant changes in all regions ranging above 0.8.
conclusionThere was a clear distinction in DAT loss and nonmotor profiles by olfactory status in iRBD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.