Evidence map›Paper›PMID 31158714›Full record

ArticleJournal of affective disorders2019

Treatment-naïve first episode depression classification based on high-order brain functional network.

Yanting Zheng, Xiaobo Chen, Danian Li, Yujie Liu, Xin Tan, Yi Liang, Han Zhang, Shijun Qiu, Dinggang Shen

Abstract read
In one paragraph

Article in Journal of affective disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
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  6. Review
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  8. Functional MRI in major depressive disorder: A review of findings, limitations, and future prospects.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022
    Review
  9. Article
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  11. Article
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  17. Identification of Abnormal Circuit Dynamics in Major Depressive Disorder via Multiscale Neural Modeling of Resting-State fMRI.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yanting ZhengThe First School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China; Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Xiaobo ChenDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Danian LiCerebropathy Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong 510405, China.
Yujie LiuThe First School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China.
Xin TanDepartment of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong 510405, China.
Yi LiangDepartment of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong 510405, China; Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Han ZhangDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: hanzhang@med.unc.edu.
Shijun QiuDepartment of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong 510405, China. Electronic address: qiu-sj@163.com.
Dinggang ShenDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Brain and Cognitive Engineering, Korea University, Seoul 02841, Republic of Korea. Electronic address: dgshen@med.unc.edu.

Funding

Diagnosis of Alzheimer's Disease Using Dynamic High-Order Brain NetworksR01EB022880 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2016 to 2018
$1.1M
NIBIB NIH HHS R01 EB022880
6 · The paper itself

Abstract

backgroundRecent functional connectivity (FC) studies have proved the potential value of resting-state functional magnetic resonance imaging (rs-fMRI) in the study of major depressive disorder (MDD); yet, the rs-fMRI-based individualized diagnosis of MDD is still challenging.

methodsWe enrolled 82 treatment-naïve first episode depression (FED) adults and 72 matched normal control (NC). A computer-aided diagnosis framework was utilized to classify the FEDs from the NCs based on the features extracted from not only traditional "low-order" FC networks (LON) based on temporal synchronization of original rs-fMRI signals, but also "high-order" FC networks (HON) that characterize more complex functional interactions via correlation of the dynamic (time-varying) FCs. We contrasted a classifier using HON feature (C

resultsThe C LIMITATIONS: We only used one imaging modality and did not examine data from different subtypes of depression.

conclusionsDepression classification could be significantly improved by using HON features that better capture the higher-level brain functional interactions. The findings suggest the importance of higher-level cerebro-cerebellar interactions in the pathophysiology of MDD.

Indexed as

AdultBrainBrain MappingCerebellumCognitionDiagnosis, Computer-AssistedFemaleHumansMagnetic Resonance ImagingMajor Depressive DisorderMaleDepressionDiagnosisDynamic functional connectivityFunctional magnetic resonance imagingResting stateTreatment naïve

Identifiers

PMID31158714
PMCPMC6750956

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.