ArticleBrain, behavior, and immunity2019
Antenatal active maternal asthma and other atopic disorders is associated with ADHD behaviors among school-aged children.
Article in Brain, behavior, and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Association and Interacting Factors between Bronchial Asthma and Attention-deficit Hyperactivity Disorder in Children: Meta-analysis and Systematic Review.Actas espanolas de psiquiatria · 2023Pooled it
- Two meta-analyses of the association between atopic diseases and core symptoms of attention deficit hyperactivity disorder.Scientific reports · 2022Pooled it
- Maternal immune activation in mice recapitulates features of attention-deficit/hyperactivity disorder (ADHD) in susceptible offspring.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Maternal immune-mediated conditions and ADHD risk in offspring.BMC medicine · 2025Article
- Maternal asthma and asthma exacerbation during pregnancy and attention-deficit/hyperactivity disorder in offspring: a population-based cohort study.European child & adolescent psychiatry · 2024Article
- Rhinorrhea and watery eyes in infancy and risk of attention-deficit hyperactivity disorder in school-age children.Developmental psychobiology · 2024Article
- Offspring behavioral outcomes following maternal allergic asthma in the IL-4-deficient mouse.Journal of neuroimmunology · 2024Article
- Omalizumab in combination with subcutaneous immunotherapy for the treatment of multiple allergies associated with attention-deficit/hyperactivity disorder: a case report and a literature review.Frontiers in pharmacology · 2024Article
- Comorbidity of asthma in patients with attention-deficit/hyperactivity disorder (ADHD) aged 4-12 years in Iran: a cross-sectional study.Annals of medicine and surgery (2012) · 2023Article
- Article
- Association between atopic diseases and neurodevelopmental disabilities in a longitudinal birth cohort.Autism research : official journal of the International Society for Autism Research · 2022Article
- S3 guideline Allergy Prevention.Allergologie select · 2022Article
- Statistical analysis of childhood and early adolescent externalizing behaviors in a middle low income country.Heliyon · 2020Article
- Understanding the Link Between Allergy and Neurodevelopmental Disorders: A Current Review of Factors and Mechanisms.Frontiers in neurology · 2020Review
- Parental asthma occurrence, exacerbations and risk of attention-deficit/hyperactivity disorder.Brain, behavior, and immunity · 2019Article
- Prevalence and Risk Factors of Attention Deficit-Hyperactivity Disorder in the Saudi Population: A Systematic Review and Meta-analysis.Saudi journal of medicine & medical sciencesArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIdentifying modifiable risk factors for neuropsychological correlates of attention deficit hyperactivity disorder (ADHD) in early childhood can inform prevention strategies. Prenatal inflammatory states, such as maternal asthma and other atopic disorders, have been increasingly linked to enhanced risk for neurobehavioral disorders in children, with some studies suggesting sex-specific effects.
objectivesTo assess the association between maternal active asthma and/or atopy in the antenatal period and child symptoms of ADHD during mid-childhood and, given the male-bias in ADHD prevalence, to examine modifying effects of child sex. STUDY
designThe study sample includes 250 maternal-child pairs enrolled in the Boston-based Asthma Coalition on Community, Environment and Social Stress (ACCESS) pregnancy cohort. We defined antenatal active atopy based on maternal report of current asthma, allergic rhinitis or atopic dermatitis during and/or in the year before pregnancy. When children were approximately 6 years old, mothers completed a battery of standardized child behavior rating scales designed for evaluating symptoms of ADHD. We used multivariable quantile regression to assess the relations between maternal antenatal atopy and symptoms of ADHD among children.
resultsIn adjusted models, maternal atopy was significantly associated with greater risk for ADHD behaviors, as indicated by scores on the Conners' Parent Rating Scale-Revised ADHD index (β = 3.32, 95% CI: 0.33, 6.32). In sex-stratified models this association was stronger among girls (5.96, 95% CI = 0.95, 10.96) compared to boys (-2.14, 95% CI = -5.75, 1.45, p-interaction = 0.01). Among girls, we observed a similar finding for the Behavior Assessment System for Children 2nd Edition Parent Rating Scale Attention Problems subscale (β = 7.77, 95% CI = 1.57, 13.97). Results from other outcome subscales were similar in magnitude and direction, however, associations did not reach statistical significance at the p = 0.05 level.
conclusionsMaternal antenatal active atopy may be a risk factor for the development of ADHD-like symptoms, especially among girls.
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