ArticleOsteoarthritis and cartilage2019
The association between asymptomatic hyperuricemia and knee osteoarthritis: data from the third National Health and Nutrition Examination Survey.
Article in Osteoarthritis and cartilage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 30 citations in OpenAlex.
- Circulating Metabolic Factors Mediating the Effect of Obesity-Related Indicators on Meniscal Injuries: A Mendelian Randomization Study.International journal of genomics · 2026Article
- The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms.Frontiers in endocrinology · 2025Review
- Weight change patterns across adulthood are associated with the risk of osteoarthritis: a population-based study.Aging clinical and experimental research · 2024Article
- Impact of health literacy, social support, and socioeconomic position on the serum uric acid level in asymptomatic hyperuricaemia patients in China: a structural equation model.BMC public health · 2024Article
- Association between asymptomatic hyperuricemia and risk of arthritis, findings from a US National Survey 2007-2018.BMJ open · 2024Article
- Association between hyperuricaemia and hand osteoarthritis: data from the Xiangya Osteoarthritis Study.RMD open · 2023Observational
- Validating Knee Varus Alignment Measurements Using Markerless Motion Capture.Geriatrics (Basel, Switzerland) · 2023Article
- ULTRASONOGRAPHIC EVALUATION OF FEMORAL CARTILAGE THICKNESS IN PARTICIPANTS WITH ASYMPTOMATIC HYPERURICEMIA: A CASE-CONTROL STUDY.Acta clinica Croatica · 2023Article
- TGF-β is elevated in hyperuricemic individuals and mediates urate-induced hyperinflammatory phenotype in human mononuclear cells.Arthritis research & therapy · 2023Article
- Osteoarthritis or arthritis? Toward understanding of primary Sjögren's syndrome patients with arthralgia.Journal of orthopaedic surgery and research · 2023Article
- Expression of miR-204 in patients with osteoarthritis and its damage to chondrocytes.Journal of musculoskeletal & neuronal interactions · 2020Article
- Hyperuricemia is associated with intermittent hand joint pain in a cross sectional study of elderly females: The AGES-Reykjavik Study.PloS one · 2019Article
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Authors and funding
4 authors at 4 institutions in 2 countries.
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Abstract
objectiveIn vitro and clinical studies suggest that urate may contribute to osteoarthritis (OA) risk. We tested the associations between hyperuricemia and knee OA, and examined the role of obesity, using a cross-sectional, nationally representative dataset.
methodNational Health and Nutrition Examination Survey (NHANES) III used a multistage, stratified probability cluster design to select USA civilians from 1988 to 1994. Using NHANES III we studied adults >60 years, with or without hyperuricemia (serum urate > 6.8 mg/dL), excluding individuals with gout (i.e., limiting to asymptomatic hyperuricemia (AH)). Radiographic knee OA (RKOA) was defined as Kellgren-Lawrence grade ≥ 2 in any knee, and symptomatic radiographic knee osteoarthritis (RKOA) (sRKOA) was defined as RKOA plus knee pain (most days for 6 weeks) in the same knee.
resultsAH prevalence was 17.9% (confidence interval (CI) 15.3-20.5). RKOA prevalence was 37.7% overall (CI 35.0-40.3), and was 44.0% for AH vs 36.3% for normouricemic adults (p = 0.056). symptomatic radiographic knee osteoarthritis (sRKOA) was more prevalent in AH vs normouricemic adults (17.4% vs 10.9%, p = 0.046). In multivariate models adjusting for obesity, model-based associations between AH and knee OA were attenuated (for RKOA, prevalence ratio (PR) = 1.14, 95% CI 0.95, 1.36; for sRKOA, PR = 1.40, 95% CI 0.98, 2.01). In stratified multivariate analyses, AH was associated with sRKOA in adults without obesity (PR = 1.66, 95% CI 1.02, 2.71) but not adults with obesity (PR = 1.21, 95% CI 0.66, 2.23).
conclusionsAmong adults aged 60 or older, AH is associated with knee OA risk that is more apparent in adults without obesity.
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