ArticleExperimental eye research2019
Noninvasive imaging of the tree shrew eye: Wavefront analysis and retinal imaging with correlative histology.
Article in Experimental eye research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 50 citations in OpenAlex.
- Measuring electroretinograms in tree shrews with a portable electrophysiology device.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Evaluation of Shack-Hartmann wavefront sensing artifacts due to reflectivity variations across thick layered samples using the discrete Fourier transform.Biomedical optics express · 2026Article
- Article
- ƒ(Cell): Software for Reproducible Analysis of Optoretinograms.Translational vision science & technology · 2026Article
- Tree shrew model of early diabetic retinopathy reveals microvascular dysfunction and identifies phosphoserine aminotransferase 1 as a novel therapeutic target.Animal models and experimental medicine · 2026Article
- Visual field of the ferret (Mustela putorius furo), rat (Rattus norvegicus), and tree shrew (Tupaia belangeri).Journal of vision · 2025Article
- Mapping function in the tree shrew visual system using functional ultrasound imaging.bioRxiv : the preprint server for biology · 2025Article
- Early Peripapillary Choroidal Thinning during Myopia Development: A Potential Biomarker for Progressive Myopia Identified in Tree Shrews.Investigative ophthalmology & visual science · 2025Article
- Non-aversive Animal Restraint Enabling Recording of Optomotor Reflex in Ground Squirrels.Journal of visualized experiments : JoVE · 2025Article
- Is central vision (and a fovea) needed for emmetropisation?Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Article
- Optimizing procedures for ocular radiation injury studies in the tree shrew.Exploration of targeted anti-tumor therapy · 2025Article
- Unexpected Retinal Abnormalities in the Cone-Dominant Northern Tree Shrew.Advances in experimental medicine and biology · 2025Article
- Visible-Light Optical Coherence Tomography Fibergraphy of the Tree Shrew Retinal Ganglion Cell Axon Bundles.IEEE transactions on medical imaging · 2024Article
- Study of tree shrew biology and models: A booming and prosperous field for biomedical research.Zoological research · 2024Review
- The Parameters Governing the Anti-Myopia Efficacy of Chromatically Simulated Myopic Defocus in Tree Shrews.Translational vision science & technology · 2024Article
- Article
- Heterogenous thinning of peripapillary tissues occurs early during high myopia development in juvenile tree shrews.Experimental eye research · 2024Article
- The Mongolian gerbil as an advanced model to study cone system physiology.Frontiers in cellular neuroscience · 2024Article
- Cellular Characterization and Interspecies Evolution of the Tree Shrew Retina across Postnatal Lifespan.Research (Washington, D.C.) · 2024Article
- The effects of intensity, spectral purity and duty cycle on red light-induced hyperopia in tree shrews.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2023Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
Tree shrews are small mammals with excellent vision and are closely related to primates. They have been used extensively as a model for studying refractive development, myopia, and central visual processing and are becoming an important model for vision research. Their cone dominant retina (∼95% cones) provides a potential avenue to create new damage/disease models of human macular pathology and to monitor progression or treatment response. To continue the development of the tree shrew as an animal model, we provide here the first measurements of higher order aberrations along with adaptive optics scanning light ophthalmoscopy (AOSLO) images of the photoreceptor mosaic in the tree shrew retina. To compare intra-animal in vivo and ex vivo cone density measurements, the AOSLO images were matched to whole-mount immunofluorescence microscopy. Analysis of the tree shrew wavefront indicated that the optics are well-matched to the sampling of the cone mosaic and is consistent with the suggestion that juvenile tree shrews are nearly emmetropic (slightly hyperopic). Compared with in vivo measurements, consistently higher cone density was measured ex vivo, likely due to tissue shrinkage during histological processing. Tree shrews also possess massive mitochondria ("megamitochondria") in their cone inner segments, providing a natural model to assess how mitochondrial size affects in vivo retinal imagery. Intra-animal in vivo and ex vivo axial distance measurements were made in the outer retina with optical coherence tomography (OCT) and transmission electron microscopy (TEM), respectively, to determine the origin of sub-cellular cone reflectivity seen on OCT. These results demonstrate that these megamitochondria create an additional hyper-reflective outer retinal reflective band in OCT images. The ability to use noninvasive retinal imaging in tree shrews supports development of this species as a model of cone disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.