Trial reportEuropean urology oncology2018
Functional and Oncologic Outcomes Between Open and Robotic Radical Prostatectomy at 24-month Follow-up in the Swedish LAPPRO Trial.
Trial report in European urology oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Robot-assisted versus open radical prostatectomy: a systematic review and meta-analysis of prospective studies.Journal of robotic surgery · 2023Pooled it
- Risk of erectile dysfunction after modern radiotherapy for intact prostate cancer.Prostate cancer and prostatic diseases · 2021Pooled it
- Accuracy of the LaserSAFE technique for detecting positive surgical margins during robot-assisted radical prostatectomy: blind assessment and inter-rater agreement analysis.Histopathology · 2025Trial
- Functional and quality of life outcomes of localised prostate cancer treatments (Prostate Testing for Cancer and Treatment [ProtecT] study).BJU international · 2022Trial
- Variation across operating sites in urinary and sexual outcomes after radical prostatectomy in localized and locally advanced prostate cancer.World journal of urology · 2022Trial
- Urinary continence recovery and oncological outcomes after surgery for prostate cancer analysed by risk category: results from the LAParoscopic prostatectomy robot and open trial.World journal of urology · 2021Trial
- Open vs. robotic prostatectomy using VersiusJournal of robotic surgery · 2026Observational
- Early experience with robot-assisted radical prostatectomy using the Toumai system: outcomes from the first African series of 134 patients.Journal of robotic surgery · 2026Article
- Comparative functional, perioperative and oncological outcomes of robot-assisted and open radical prostatectomy: a systematic review and meta-analysis.International urology and nephrology · 2026Review
- Increasing Age at Radical Prostatectomy: A Total Population Analysis in Germany from 2006 to 2022.Annals of surgical oncology · 2026Article
- Robot-AssistedThe world journal of men's health · 2026Article
- Application Effect of Different Robotic Surgery Systems in Radical Prostatectomy: A Comparative Study Based on a Network Meta-analysis.European urology open science · 2025Review
- [Functional outcomes after robot-assisted laparoscopic prostatectomy (RALP) vs. open radical retropubic prostatectomy (RRP): critical analysis in the context of current evidence].Urologie (Heidelberg, Germany) · 2025Article
- Adverse events during radical prostatectomy and their association with recurrence and death.World journal of urology · 2025Article
- Engineering NIR probes to enhance affinity and clinical workflow compatibility for prostate cancer imaging.bioRxiv : the preprint server for biology · 2025Article
- Advances in Techniques in Radical Prostatectomy.Medicina (Kaunas, Lithuania) · 2025Review
- Comparison of perioperative and oncological outcomes between two different surgical procedures for the treatment of prostate cancer.Translational andrology and urology · 2025Article
- Navigating Focal Therapy for Prostate Cancer: Contemporary Perspectives and Future Trajectories in the Canadian Context.Journal of endourology · 2025Review
- Article
- Robot-assisted radical prostatectomy with the Versius surgical platform: An objective criticism and a guide for an optimal surgical setup.Arab journal of urology · 2025Article
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundThe adoption of robot-assisted laparoscopic radical prostatectomy (RALP) has increased rapidly, despite lack of conclusive evidence of its superiority regarding long-term outcomes over open retropubic RP (RRP). In 2015, we reported on 12-mo follow-up from the LAPPRO trial showing a moderate advantage of RALP regarding erectile dysfunction. No significant differences were seen for urinary incontinence or surgical margin status.
objectiveTo present patient-reported functional outcomes and recurrent and residual disease at 24-mo follow-up from the prospective multicenter LAPPRO trial. DESIGN, SETTING, AND
participantsA total of 4003 patients with clinically localized prostate cancer were recruited from 14 Swedish centers, seven performing RALP and seven RRP. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Data were only analyzed for patients operated on by surgeons with >100 prior RPs. Adjusted odds ratios (AORs) were calculated using logistic regression, with adjustment for differences in patient mix. RESULTS AND LIMITATIONS: At 24 mo, there was a significant difference in erectile dysfunction in favor of RALP (68% vs 74%; AOR 0.72, 95% confidence interval [CI] 0.57-0.91; p=0.006). No significant difference was observed for incontinence (19% vs 16%; AOR 1.29, 95% CI 1.00-1.67; p=0.053) or recurrent or residual disease (13% vs 13%; AOR 0.79, 95% CI 0.59-1.07; p=0.13). We did not adjust for individual surgeon volume and experience, which is a potential limitation.
conclusionsExtended follow-up corroborated our previous report at 12 mo of a persistent RALP benefit regarding potency. PATIENT SUMMARY: LAPPRO is a Swedish trial comparing two different prostate cancer surgical techniques (robotic compared to open). At 24-mo follow-up after surgery there was a moderate advantage for the robotic technique regarding erectile dysfunction (potency), while there was a small but not significant difference in urinary leakage in favor of open surgery. We did not find any difference regarding cancer relapse.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.