Evidence map›Paper›PMID 31157724›Full record

ArticleOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology2019

Histopathologic Characteristics of Internal Auditory Canal Diverticula.

Thomas Muelleman, Anne K Maxwell, Ivan Lopez, Fred Linthicum, Akira Ishiyama, Luke Ledbetter, James Lin, Hinrich Staecker, Mia Miller

Abstract read
In one paragraph

Article in Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Current trends in imaging for otosclerosis and the potential role of photon-counting computed tomography.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thomas MuellemanHouse Ear Institute.
Anne K MaxwellHouse Ear Institute.
Ivan LopezDepartment of Head and Neck Surgery, University of California Los Angeles, Los Angeles, California.
Fred LinthicumHouse Ear Institute.
Akira IshiyamaDepartment of Head and Neck Surgery, University of California Los Angeles, Los Angeles, California.
Luke LedbetterDepartment of Radiology.
James LinDepartment of Otolaryngology-Head and Neck Surgery, University of Kansas, Kansas.
Hinrich StaeckerDepartment of Otolaryngology-Head and Neck Surgery, University of Kansas, Kansas.
Mia MillerHouse Ear Institute.

Funding

The Human Temporal Bone Laboratory Resource for Basic and Applied Inner Ear SciencesU24DC015910 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ISHIYAMA, AKIRA · 2017 to 2022
$4.2M
NIDCD NIH HHS U24 DC015910
6 · The paper itself

Abstract

hypothesisWe hypothesize that internal auditory canal (IAC) diverticula occur independent of otosclerosis as demonstrated by temporal bone histopathology.

backgroundDiverticula at the anterior-inferior aspect of the IAC have been described histologically in the setting of cavitary otosclerosis. Recent radiographic studies show the prevalence of IAC diverticula that is higher than what can be accounted for by cavitary otosclerosis alone.

methodsWe examined hematoxylin and eosin temporal bone histopathology slides with otosclerosis involving the IAC. We also examined bones from normal hearing subjects with normal histologic findings. Temporal bones were included if donors were more than 18 years of age at time of death and adequate horizontal cuts were available to evaluate the area of interest.

resultsIAC diverticula were found in 33 of 47 (70%) temporal bones with IAC otosclerosis and in 5 of 20 (25%) normal temporal bones. The difference in mean pure tone averages (PTA) in the normal temporal bones with (PTA 7.3 ± 7) and without (PTA 8 ± 2) diverticula was not statistically significant (p = 0.86).

conclusionIAC diverticula which have been previously demonstrated to occur in the setting of cavitary otosclerosis can also occur independent from otosclerosis. Subjects with diverticula but without other temporal bone pathology have normal hearing thresholds.

Indexed as

AgedDiverticulumEar, InnerFemaleHearingHearing TestsHumansMaleOtosclerosisTemporal Bone

Identifiers

PMID31157724
PMCPMC6565456

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