Evidence map›Paper›PMID 31157588›Full record

ArticleCell cycle (Georgetown, Tex.)2019

Circular RNA 0047905 acts as a sponge for microRNA4516 and microRNA1227-5p, initiating gastric cancer progression.

Zhiyong Lai, Yang Yang, Chaobing Wang, Wenhui Yang, Yichao Yan, Zhu Wang, Jun Xu, Kewei Jiang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
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  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Non-coding RNAs underlying chemoresistance in gastric cancer.Cellular oncology (Dordrecht, Netherlands) · 2020
    Review
  11. Article
  12. Article
  13. Review
  14. Current Understanding of Circular RNAs in Gastric Cancer.Cancer management and research · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Zhiyong Laia Department of General Surgery , Shanxi Dayi Hospital, Shanxi Academy of Medical Sciences , Taiyuan , Shanxi , People's Republic of China.
Yang Yangb Department of Breast Center , Peking University People's Hospital , Beijing , People's Republic of China.
Chaobing Wangb Department of Breast Center , Peking University People's Hospital , Beijing , People's Republic of China.
Wenhui Yangc Department of Biochemistry and Molecular Biology , Shanxi Medical University , Taiyuan , People's Republic of China.
Yichao Yand Department of Gastroenterological Surgery , Peking University International Hospital , Beijing , People's Republic of China.
Zhu Wange Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research , Peking University People's Hospital , Beijing , People's Republic of China.
Jun Xua Department of General Surgery , Shanxi Dayi Hospital, Shanxi Academy of Medical Sciences , Taiyuan , Shanxi , People's Republic of China.
Kewei Jiange Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research , Peking University People's Hospital , Beijing , People's Republic of China.
Peking University People's Hospital · CNPeking University · CNPeking University International Hospital · CNShanxi Academy of Medical Sciences · CNShanxi Dayi Hospital · CNShanxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several lines of evidence suggest that circular RNAs (circRNAs) play important roles in oncogenesis and tumor progression. However, our knowledge of the role of circRNAs in gastric cancer (GC) remains limited. We investigated the possibility that circular RNA 0047905 (circRNA0047905) might act as a tumor promoter in the pathogenesis of gastric cancer by profiling miRNA expression in GC tissues and paired noncancerous mucosa tissues using miRNA microarrays. Next, a ceRNA network was constructed according to common miRNAs binding circRNAs and mRNAs. Mechanistically, we demonstrated that circRNA0047905 directly binds miR4516 and miR1227-5p, relieving suppression for targets SERPINB5 and MMP11. We observed that down-regulated circRNA0047905 expression in gastric cancer cells inhibited Akt/CREB signaling pathway activation. RNA scope in situ hybridization revealed expression of circRNA0047905 in GC. Our data suggest that circRNA0047905 is a promising target for GC diagnosis and therapy.

Indexed as

CarcinogenesisCell Line, TumorCell MovementCell ProliferationCyclic AMP Response Element-Binding ProteinDown-RegulationGene Expression Regulation, NeoplasticHumansMatrix Metalloproteinase 11Microarray AnalysisMicroRNAsPrognosisProto-Oncogene Proteins c-aktRNA, CircularSerpinsSignal TransductionCREB1 protein, humanCyclic AMP Response Element-Binding ProteinMatrix Metalloproteinase 11MicroRNAsMMP11 protein, humanProto-Oncogene Proteins c-aktRNA, CircularSERPIN-B5SerpinscircRNA0047905competing endogenous RNAgastric canceroncogenesis

Identifiers

PMID31157588
PMCPMC6619930
OpenAlexW2948391077

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.