Evidence map›Paper›PMID 31157548›Full record

ArticleBiomarkers in medicine2019

Expression of p16 and p53 in non-small-cell lung cancer: clinicopathological correlation and potential prognostic impact.

Yangying Zhou, Naseruddin Höti, Minghui Ao, Zhen Zhang, Hong Zhu, Ling Li, Frederic Askin, Edward Gabrielson, Hui Zhang, Qing Kay Li

Open access · greenAbstract read
In one paragraph

Article in Biomarkers in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. p16 Beyond Senescence: Cancer Biology Lessons Applied to Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
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  16. Article
  17. Review
  18. Article
  19. Annals of translational medicine · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Yangying ZhouDepartment of Oncology, Xiangya Hospital, Central South University, Changsha 410008, PR China.
Naseruddin HötiDepartment of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA.
Minghui AoDepartment of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA.
Zhen ZhangDepartment of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA.
Hong ZhuDepartment of Oncology, Xiangya Hospital, Central South University, Changsha 410008, PR China.
Ling LiDepartment of Pathology, School of Basic Medical Science, Hangzhou Medical College, Hangzhou 310053, PR China.
Frederic AskinDepartment of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA.
Edward GabrielsonDepartment of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA.
Hui ZhangDepartment of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA.
Qing Kay LiDepartment of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA.
Sidney Kimmel Comprehensive Cancer Center · USJohns Hopkins University · USCentral South University · CNHangzhou Medical College · CNXiangya Hospital Central South University · CN

Funding

Glycoprotein biomarkers for the early detection of aggressive prostate cancerU01CA152813 · NCI · JOHNS HOPKINS UNIVERSITY · PI ZHANG, HUI · 2010 to 2021
$6.2M
NCI NIH HHS U01 CA152813
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adenocarcinoma of LungAdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellCyclin-Dependent Kinase Inhibitor p16FemaleHumansImmunohistochemistryIn Situ HybridizationKaplan-Meier EstimateLung NeoplasmsMaleMiddle AgedBiomarkers, TumorCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16TP53 protein, humanTumor Suppressor Protein p53adenocarcinomasbiomarkerclinical survivalHPVhuman papilloma virushybridizationimmunohistochemistrynon-small-cell lung carcinomap16p53squamous cell carcinomas

Identifiers

PMID31157548
PMCPMC8173521
OpenAlexW2949010790

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.