ArticleFrontiers in bioengineering and biotechnology2019
Investigating the Effect of Aging on the Viscosity of Tendon Fascicles and Fibers.
Article in Frontiers in bioengineering and biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Decorin and/or biglycan knockdown in aged mouse patellar tendon impacts fibril morphology, scar area, and mechanical properties.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Intermittent cyclic stretch of engineered ligaments drives hierarchical collagen fiber maturation in a dose- and organizational-dependent manner.Acta biomaterialia · 2024Article
- Characterizing and Engineering Biomimetic Materials for Viscoelastic Mechanotransduction Studies.Tissue engineering. Part B, Reviews · 2022Review
- Aging and matrix viscoelasticity affect multiscale tendon properties and tendon derived cell behavior.Acta biomaterialia · 2022Article
- Engineering Gels with Time-Evolving Viscoelasticity.Materials (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the current work, we investigate the effect of aging on the viscosity of tendon subunits. To that scope, we make use of experimental relaxation curves of healthy and aged tendon fascicles and fibers, upon which we identify the viscosity parameters characterizing the time-dependent behavior of each tendon subunit. We subsequently combine the obtained results with analytical viscoelastic homogenization analysis methods to extract information on the effective viscous contribution of the embedding matrix substance at the fiber scale. The results suggest that the matrix substance plays a significant role in the relaxation process of the upper tendon subunits both for aged and healthy specimens. What is more, the viscosity coefficients computed for the fibrillar components indicate that aging leads to a viscosity reduction that is statistically significant for both fascicles and fibers. Its impact is more prominent for the lower hierarchical scale of fibers. As such, the reduced stress relaxation capability at the tendon macroscale is to be primarily attributed to the modified viscosity of its inner fibrillar subunits rather than to the matrix substance.
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Registered trials
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