Evidence map›Paper›PMID 31157175›Full record

ArticleFrontiers in cellular and infection microbiology2019

Suppression of Alternative Lipooligosaccharide Glycosyltransferase Activity by UDP-Galactose Epimerase Enhances Murine Lung Infection and Evasion of Serum IgM.

Sandy M Wong, Mary Darby Jackson, Brian J Akerley

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Molecular Mimicry Mapping inPathogens (Basel, Switzerland) · 2023
    Article
  5. Microbiology spectrum · 2023
    Article
  6. Article
  7. Learning from -omics strategies applied to uncoverComputational and structural biotechnology journal · 2021
    Review
  8. Inactivation of theMicroorganisms · 2020
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sandy M WongDepartment of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, MS, United States.
Mary Darby JacksonDepartment of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, MS, United States.
Brian J AkerleyDepartment of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, MS, United States.
University of Mississippi Medical Center · US

Funding

Mechanisms of Haemophilus influenzae pathogenesis in the lungR01AI095740 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI AKERLEY, BRIAN, SHEN, HAO · 2012 to 2016
$1.8M
NIAID NIH HHS R01 AI095740
6 · The paper itself

Abstract

In pathogens that produce lipooligosaccharide (LOS), sugar residues within the surface-exposed LOS outer core mediate interactions with components of the host immune system, promoting bacterial infection. Many LOS structures are controlled by phase variation mediated by random slipped-strand base mispairing, which can reversibly switch gene expression on or off. Phase variation diversifies the LOS, however its adaptive role is not well-understood. Nontypeable

Indexed as

Immune EvasionAnimalsBacterial ProteinsBiofilmsComplement System ProteinsDisease Models, AnimalGene DeletionGene ExpressionGlycosyltransferasesHaemophilus InfectionsHaemophilus influenzaeHumansImmunoglobulin MLipopolysaccharidesLungMiceBacterial ProteinsComplement System ProteinsGlycosyltransferasesImmunoglobulin Mlic2A protein, Haemophilus influenzaelipid-linked oligosaccharidesLipopolysaccharidesUDPglucose 4-EpimeraseUridine DiphosphateUridine Diphosphate GalactoseUridine Diphosphate GlucoseHaemophilus influenzaeHITSimmune evasionlipooligosaccharide (LOS)lung infectionNTHiTn-seq

Identifiers

PMID31157175
PMCPMC6530457
OpenAlexW2945286329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.