Evidence map›Paper›PMID 31157159›Full record

ArticleChemElectroChem2018

Quantitative Electrochemical DNA Microarray on a Monolith Electrode with Ten Attomolar Sensitivity, 100% Specificity, and Zero Background.

Shobana Raghunath, Abhijeet Prasad, Rahul Tevatia, Jillian R Gunther, Santanu Roy, Sunil Krishnan, Ravi F Saraf

Open access · greenAbstract read
In one paragraph

Article in ChemElectroChem, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Shobana RaghunathVajra Instruments, Inc.Lincoln, NE 68512 USA.
Abhijeet PrasadVajra Instruments, Inc.Lincoln, NE 68512 USA.
Rahul TevatiaChemical Engineering, University of Nebraska Lincoln, NE 68588 USA.
Jillian R GuntherMD Anderson Cancer Research Center Houston, TX 77030 USA.
Santanu RoyVajra Instruments, Inc.Lincoln, NE 68512 USA.
Sunil KrishnanMD Anderson Cancer Research Center Houston, TX 77030 USA.
Ravi F SarafChemical Engineering, University of Nebraska Lincoln, NE 68588 USA.
University of Nebraska–Lincoln · USLincoln Electric (United States) · USThe University of Texas MD Anderson Cancer Center · US

Funding

A Prognostic Blood Test to Monitor Pancreatic Cancer Treatment by MiRNA ProfilingR44CA199058 · NCI · VAJRA INSTRUMENTS, INC. · PI SARAF, RAVI · 2018 to 2019
$2.0M
Profiling Circulating miRNA Without PCR for Early Detection of Pancreatic CancerR43CA199058 · NCI · VAJRA INSTRUMENTS, INC. · PI ROY, SANTANU, SARAF, RAVI · 2015 to 2015
$293k
NCI NIH HHS R43 CA199058NCI NIH HHS R44 CA199058
6 · The paper itself

Abstract

Circulating microRNA are promising diagnostic and prognostic biomarkers of disease in quantitative blood tests. A label-free, PCR-free, electrochemical microarray technology on a monolith electrode is described, with 10 attomolar (aM) sensitivity and responsiveness to binding of <1 zeptomole of target to immobilized ssDNA probes with zero background. Specificity is 100% in a mixture with five nonspecific miRNA each with a 10

Indexed as

blood testcancer diagnosisDNA sequencingelectrochemical analysismicroarraymicroRNA

Identifiers

PMID31157159
PMCPMC6541448
OpenAlexW2770878767

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.