Evidence map›Paper›PMID 31157152›Full record

ArticleGlobal spine journal2019

Essential Concepts for the Management of Metastatic Spine Disease: What the Surgeon Should Know and Practice.

Ori Barzilai, Stefano Boriani, Charles G Fisher, Arjun Sahgal, Jorrit Jan Verlaan, Ziya L Gokaslan, Aron Lazary, Chetan Bettegowda, Laurence D Rhines, Ilya Laufer

Abstract read
In one paragraph

Article in Global spine journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  18. Predictive factors for respiratory failure and in-hospital mortality after surgery for spinal metastasis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ori BarzilaiMemorial Sloan-Kettering Cancer Center, New York, NY.ORCID https://orcid.org/0000-0002-4037-8716
Stefano BorianiIRCCS Galeazzi Orthopedic Institute, Milan, Italy.
Charles G FisherUniversity of British Columbia, Vancouver, British Columbia, Canada.
Arjun SahgalUniversity Medical Center Utrecht, Utrecht, the Netherlands.
Jorrit Jan VerlaanUniversity Medical Center Utrecht, Utrecht, the Netherlands.
Ziya L GokaslanThe Warren Alpert Medical School of Brown University, Providence, RI, USA.
Aron LazaryNational Center for Spinal Disorders and Buda Health Center, Budapest, Hungary.
Chetan BettegowdaJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Laurence D RhinesThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ilya LauferMemorial Sloan-Kettering Cancer Center, New York, NY.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

STUDY

designLiterature review.

objectiveTo provide an overview of the recent advances in spinal oncology, emphasizing the key role of the surgeon in the treatment of patients with spinal metastatic tumors.

methodsLiterature review.

resultsTherapeutic advances led to longer survival times among cancer patients, placing significant emphasis on durable local control, optimization of quality of life, and daily function for patients with spinal metastatic tumors. Recent integration of modern diagnostic tools, precision oncologic treatment, and widespread use of new technologies has transformed the treatment of spinal metastases. Currently, multidisciplinary spinal oncology teams include spinal surgeons, radiation and medical oncologists, pain and rehabilitation specialists, and interventional radiologists. Consistent use of common language facilitates communication, definition of treatment indications and outcomes, alongside comparative clinical research. The main parameters used to characterize patients with spinal metastases include functional status and health-related quality of life, the spinal instability neoplastic score, the epidural spinal cord compression scale, tumor histology, and genomic profile.

conclusionsStereotactic body radiotherapy revolutionized spinal oncology through delivery of durable local tumor control regardless of tumor histology. Currently, the major surgical indications include mechanical instability and high-grade spinal cord compression, when applicable, with surgery providing notable improvement in the quality of life and functional status for appropriately selected patients. Surgical trends include less invasive surgery with emphasis on durable local control and spinal stabilization.

Indexed as

metastasesoncologystereotactic body therapy (SBRT)surgerytumors

Identifiers

PMID31157152
PMCPMC6512191

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.