Evidence map›Paper›PMID 31157117›Full record

ArticleEuropean Medical Journal. Reproductive health2017

Regenerative Medicine, Disease Modeling, and Drug Discovery in Human Pluripotent Stem Cell-derived Kidney Tissue.

Navin Gupta, Koichiro Susa, Ryuji Morizane

Abstract read
In one paragraph

Article in European Medical Journal. Reproductive health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Cryopreservation of human kidney organoids.Cellular and molecular life sciences : CMLS · 2024
    Article
  3. Review
  4. Single-cell RNA sequencing and kidney organoid differentiation.Clinical and experimental nephrology · 2023
    Review
  5. ATP/ADP biosensor organoids for drug nephrotoxicity assessment.Frontiers in cell and developmental biology · 2023
    Article
  6. Kidney organoids: a pioneering model for kidney diseases.Translational research : the journal of laboratory and clinical medicine · 2022
    Review
  7. 3D kidney organoids for bench-to-bedside translation.Journal of molecular medicine (Berlin, Germany) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Navin GuptaDepartment of Medicine, Renal Division, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.
Koichiro SusaDepartment of Medicine, Renal Division, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.
Ryuji MorizaneDepartment of Medicine, Renal Division, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.

Funding

TRAINING PROGRAM IN ACADEMIC NEPHROLOGYT32DK007527 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 1986 to 2021
$8.8M
Kidney Microphysiological Analysis Platforms (MAP) to Optimize Function and Model DiseaseUG3TR002155 · NCATS · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT, LEE, LUKE P. · 2017 to 2018
$2.0M
NCATS NIH HHS UG3 TR002155NIDDK NIH HHS T32 DK007527
6 · The paper itself

Abstract

The multitude of research clarifying critical factors in embryonic organ development has been instrumental in human stem cell research. Mammalian organogenesis serves as the archetype for directed differentiation protocols, subdividing the process into a series of distinct intermediate stages that can be chemically induced and monitored for the expression of stage-specific markers. Significant advances over the past few years include established directed differentiation protocols of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) into human kidney organoids

Indexed as

Directed differentiationGlomeruliiPSKidneyKidney developmentmini-organOrganoidPluripotent stem cellTissue engineering

Identifiers

PMID31157117
PMCPMC6544146

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.