ArticleEuropean journal of hospital pharmacy : science and practice2018
Stability of warfarin sodium flavoured preservative-free oral liquid formulations.
Article in European journal of hospital pharmacy : science and practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Taste-Masked Microparticles of Sodium Warfarin Prepared by Hot Melt Extrusion and Thermal Postprocessing.Pharmaceutics · 2026Article
- Taste-Masked Pellets of Warfarin Sodium: Formulation towards the Dose Personalisation.Pharmaceutics · 2024Article
- Compounded Nonsterile Preparations and FDA-Approved Commercially Available Liquid Products for Children: A North American Update.Pharmaceutics · 2022Article
- Warfarin Sodium Stability in Oral Formulations.Molecules (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study was designed to assess the physicochemical stability of warfarin sodium liquid formulations stored at room temperature and under refrigeration.
methodsFormulations of warfarin sodium 1mg/mL were prepared from either powder or tablets dispersed in mixture containing deionised water, glycerin, sodium phosphate and strawberry alcohol-free concentrate flavour and stored in amber glass bottles at 25°C and 4°C. Stability indicating high-performance liquid chromatography assay procedure was used to analyse the concentration of the drug at the time of preparation and on days 7, 14, 21, 30, 45, 60 and 90. Changes in colour, taste and pH, as well as visual evidence of precipitation, were assessed for physicochemical instability.
resultsBetween day 0 and day 90, the pH of the powder and tablet formulations stored at 25°C decreased by -1.40 units and -1.16 units, respectively. There were minor changes in pH for both formulations stored at 4°C. The formulation from powder stored at 25°C and 4°C maintained at least 90% of the initial warfarin concentration for 30 days and 45 days, respectively. The formulation from tablets stored at 25°C and 4°C maintained at least 90% of initial warfarin concentration for 21 days and 30 days, respectively.
conclusionWarfarin sodium in flavoured preservative-free formulation from powder is recommended and stable in amber glass bottles for at least 30 days stored at 25°C and 45 days stored at 4°C.
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