Paracetamol and pain: the kiloton problem.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

18 citing papers in PubMed, 5 syntheses or guidelines pooled it.

1. Efficacy and Safety of Ibuprofen Plus Paracetamol in a Fixed-Dose Combination for Acute Postoperative Pain in Adults: Meta-Analysis and a Trial Sequential Analysis.CNS drugs · 2021
   Pooled it
2. Paracetamol (acetaminophen) for chronic non-cancer pain in children and adolescents.The Cochrane database of systematic reviews · 2017
   Pooled it
3. Oral paracetamol (acetaminophen) for cancer pain.The Cochrane database of systematic reviews · 2017
   Pooled it
4. Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults.The Cochrane database of systematic reviews · 2016
   Pooled it
5. Paracetamol (acetaminophen) for acute treatment of episodic tension-type headache in adults.The Cochrane database of systematic reviews · 2016
   Pooled it
6. Intravenous paracetamol does not have significant opioid-sparing effects when used as part of a multimodal analgesic protocol in dogs undergoing elective orthopaedic surgery.The Veterinary record · 2026
   Article
7. The 'Hippocratic Oath' for AI-based clinical decision support systems.BMC medical informatics and decision making · 2026
   Article
8. Paracetamol and NSAIDs in Cancer Pain Management: Evidence Review and Treatment Considerations.Current treatment options in oncology · 2026
   Review
9. Prevalence and Determinants of Self-Medication Practices among Cardiovascular Patients from Béja, North West Tunisia: A Community-Pharmacy-Based Survey.Pharmacy (Basel, Switzerland) · 2024
   Article
10. Exploring acetaminophen prodrugs and hybrids: a review.RSC advances · 2024
    Review
11. Exploring Bacterial Cellulose and a Biosurfactant as Eco-Friendly Strategies for Addressing Pharmaceutical Contaminants.Molecules (Basel, Switzerland) · 2024
    Article
12. Exploring public knowledge and perceptions regarding per os OTC pain-relieving medications: the case of paracetamol (acetaminophen).Journal of pharmaceutical policy and practice · 2023
    Article
13. Unlocking the Optimal Analgesic Potential: A Systematic Review and Meta-Analysis Comparing Intravenous, Oral, and Rectal Paracetamol in Equivalent Doses.Cureus · 2023
    Review
14. Current perceptions and use of paracetamol in dogs among veterinary surgeons working in the United Kingdom.Veterinary medicine and science · 2023
    Article
15. CommonJournal of personalized medicine · 2022
    Article
16. Paracetamol: A Review of Guideline Recommendations.Journal of clinical medicine · 2021
    Review
17. National Poison Center Calls Before vs After Availability of High-Dose Acetaminophen (Paracetamol) Tablets in Switzerland.JAMA network open · 2020
    Article
18. Dosage form suitability in vulnerable populations: A focus on paracetamol acceptability from infants to centenarians.PloS one · 2019
    Observational

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as