ArticleFrontiers in genetics2019
The Role of PTHLH in Ovarian Follicle Selection, Its Transcriptional Regulation and Genetic Effects on Egg Laying Traits in Hens.
Article in Frontiers in genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Single-Step Genomic Reaction Norm and ssGWAS Reveal Heat-Load-Dependent Genetic Architecture of Age at Puberty in Yorkshire Gilts.Animals : an open access journal from MDPI · 2026Article
- Transcriptome sequencing reveals the regulatory mechanisms during the development of small white follicles to small yellow follicles in laying hens.Poultry science · 2026Article
- A Multi-omics Atlas of Gonadal Sex Differences and Characterization of the dmrt1 Gene in Gymnocypris Eckloni Herzenstein.Marine biotechnology (New York, N.Y.) · 2026Article
- circ_0000132 Regulates Chicken Granulosa Cell Proliferation Apoptosis and E2/P4 Synthesis via miR-206 E2F5 Signaling.International journal of molecular sciences · 2025Article
- The spatio-temporal expression analysis of parathyroid hormone like hormone gene provides a new insight for bone growth of the antler tip tissue in sika deer.Animal bioscience · 2024Article
- Dynamic mRNA expression during chicken ovarian follicle development.G3 (Bethesda, Md.) · 2023Article
- Identification of new variants and candidate genes in women with familial premature ovarian insufficiency using whole-exome sequencing.Journal of assisted reproduction and genetics · 2022Article
- Effects of Growth-Related Genes on Body Measurement Traits in Wenshang Barred Chickens.The journal of poultry science · 2022Article
- miR-458b-5p regulates ovarian granulosa cells proliferation through Wnt/β-catenin signaling pathway by targeting catenin beta-1.Animal bioscience · 2021Article
- Effects of RAC1 on Proliferation of Hen Ovarian Prehierarchical Follicle Granulosa Cells.Animals : an open access journal from MDPI · 2020Article
- Transcriptomic and proteomic analyses of ovarian follicles reveal the role of VLDLR in chicken follicle selection.BMC genomics · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In hens, follicle selection is an important process affecting egg laying traits. This study investigated the role of parathyroid hormone-like hormone (PTHLH) in chicken follicle selection, its transcriptional regulation and genetic effects on egg laying traits. PTHLH and its receptor PTH1R were mainly expressed in follicles of 6-8 mm in diameter, exhibits differential expression pattern in the theca and granulosa cells of pre- and hierarchal follicles. PTHLH stimulates the proliferation of follicular granulosa and theca cells, the expression of StAR and CYP11A1 mRNA and the production of progesterone (P4) in pre-hierarchal follicles. Treatment with FSH increased PTHLH mRNA expression in pre-hierarchal follicular theca cells and hierarchal follicular granulosa cells. Two critical regions regulating chicken PTHLH transcription were revealed, each of which harbored a SNP: C>T (chr1: 72530014) for AP-1 and a SNP: A>G (chr1: 72531676). Hens with diplotype AC/GT were younger at first laying and laid more eggs at 32 weeks. The haplotype (G
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