Evidence map›Paper›PMID 31156614›Full record

ArticleFrontiers in immunology2019

Priming With Recombinant BCG Expressing Novel HIV-1 Conserved Mosaic Immunogens and Boosting With Recombinant ChAdOx1 Is Safe, Stable, and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice.

Athina Kilpeläinen, Narcís Saubi, Núria Guitart, Nathifa Moyo, Edmund G Wee, Krupa Ravi, Tomáš Hanke, Joan Joseph

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. RecombinantVaccines · 2025
    Review
  5. Article
  6. Article
  7. Engineering a dual vaccine against COVID-19 and tuberculosis.Frontiers in cellular and infection microbiology · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. AuxotrophicVaccines · 2022
    Review
  12. Review
  13. HarnessingVaccines · 2022
    Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Vaccine strategies for theNPJ vaccines · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Athina KilpeläinenAIDS Research Unit, Infectious Diseases Department, Catalan Center for HIV Vaccine Research and Development, Hospital Clínic/IDIBAPS, Barcelona, Spain.
Narcís SaubiAIDS Research Unit, Infectious Diseases Department, Catalan Center for HIV Vaccine Research and Development, Hospital Clínic/IDIBAPS, Barcelona, Spain.
Núria GuitartAIDS Research Unit, Infectious Diseases Department, Catalan Center for HIV Vaccine Research and Development, Hospital Clínic/IDIBAPS, Barcelona, Spain.
Nathifa MoyoThe Jenner Institute Laboratories, University of Oxford, Oxford, United Kingdom.
Edmund G WeeThe Jenner Institute Laboratories, University of Oxford, Oxford, United Kingdom.
Krupa RaviThe Jenner Institute Laboratories, University of Oxford, Oxford, United Kingdom.
Tomáš HankeThe Jenner Institute Laboratories, University of Oxford, Oxford, United Kingdom.
Joan JosephAIDS Research Unit, Infectious Diseases Department, Catalan Center for HIV Vaccine Research and Development, Hospital Clínic/IDIBAPS, Barcelona, Spain.
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESJenner Institute · GBKumamoto University · JPUniversity of Oxford · GB

Funding

Medical Research Council G1001757Medical Research Council MR/N023668/1
6 · The paper itself

Abstract

BCG is currently the only licensed vaccine against tuberculosis (TB) and confers protection against meningitis and miliary tuberculosis in infants, although pulmonary disease protection in adults is inconsistent. Recently, promising HIV-1 immunogens were developed, such as the T-cell immunogens "tHIVconsvX," designed using functionally conserved protein regions across group M strains, with mosaic immunogens to improve HIV-1 variant match and response breadth. In this study, we constructed an integrative

Indexed as

AIDS VaccinesAnimalsAntigens, ViralBCG VaccineFemaleHIV-1MiceMice, Inbred BALB CT-LymphocytesVaccines, Live, UnattenuatedVaccines, SyntheticAIDS VaccinesAntigens, ViralBCG VaccineVaccines, Live, UnattenuatedVaccines, SyntheticconservedHIVlive-attenuated vaccinesmycobacteriarBCGvaccine

Identifiers

PMID31156614
PMCPMC6530512
OpenAlexW2946142585

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.