ArticleFrontiers in endocrinology2019
Non-islet Cell Hypoglycemia: Case Series and Review of the Literature.
Article in Frontiers in endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- A systematic review of literature on Insulin-like growth factor-2-mediated hypoglycaemia in non-islet cell tumours.Endocrinology, diabetes & metabolism · 2024Pooled it
- Insulin-like growth factor receptor signaling in physiology and disease.Signal transduction and targeted therapy · 2026Review
- Surgical Management of Solid Tumors With Hematologic Manifestations: A Mechanism-Based Clinical Review.European journal of haematology · 2026Review
- Acromegalic features and hypoglycemia: Doege-Potter syndrome.Caspian journal of internal medicine · 2026Article
- Interdisciplinary management of a solitary fibrous tumor of the pleura complicated by Doege-Potter syndrome.JTCVS techniques · 2025Article
- Article
- Regulation and function of insulin and insulin-like growth factor receptor signalling.Nature reviews. Molecular cell biology · 2025Review
- Paraneoplastic hypoglycemia: An overview for optimal clinical guidance.Metabolism open · 2024Review
- Non-islet cell tumor hypoglycemia that required immediate surgery after a long-term asymptomatic state: recommendation for early intervention.Endocrinology, diabetes & metabolism case reports · 2024Article
- From liver to hormones: The endocrine consequences of cirrhosis.World journal of gastroenterology · 2024Review
- Unraveling the Whipple Triad: Non-Islet Cell Tumor-Induced Hypoglycemia.JCEM case reports · 2024Article
- Recurrent Hypoglycemia in a 67-Year-Old Woman with CD5- Positive Diffuse Large B-Cell Lymphoma.Clinical medicine insights. Case reports · 2024Article
- Investigation and Causes of Spontaneous (Non-Diabetic) Hypoglycaemia in Adults: Pitfalls to Avoid.Diagnostics (Basel, Switzerland) · 2023Review
- The metabolic effects of resumption of a high fat diet after weight loss are sex dependent in mice.Scientific reports · 2023Article
- A Case Report of Doege-Potter Syndrome: A Rare Cause of Hypoglycemia in a Patient without Diabetes.Journal of clinical medicine · 2023Article
- Solitary fibrous tumor with IGF-II-induced non-islet cell tumor hypoglycemia: a case report and molecular characterization by next-generation sequencing.Frontiers in oncology · 2023Article
- Case report: Severe, refractory hypoglycemia in a 9-year-old Brittany Spaniel with renal nephroblastoma.Frontiers in veterinary science · 2023Article
- IGF-2 mediated hypoglycemia and the paradox of an apparently benign lesion: a case report & review of the literature.BMC endocrine disorders · 2022Review
- Comparative Oncology: Management of Hepatic Neoplasia in Humans and Dogs.Veterinary sciences · 2022Review
- Non-islet cell tumor hypoglycemia in a patient with uterine carcinosarcoma.Gynecologic oncology reports · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Non-islet cell hypoglycemia (NICH) is hypoglycemia due to the overproduction of insulin-like growth factor-2 (IGF-2) and its precursors which can activate the insulin receptor. Typically, large mesenchymal and epithelial tumors can cause NICH. Diagnosis is confirmed by finding an elevated IGF-2/IGF-1 ratio. The mainstay of treatment is surgical excision. Glucocorticoids may be used in cases where surgery is not possible. We present two cases of NICH with different outcomes. A 33-year-old male patient admitted with altered mental. He was found walking naked outside his house. Laboratory assessment revealed severe hypoglycemia. Further evaluation showed low levels of insulin, C-peptide, and beta-hydroxybutyrate along with an elevated IGF-2/IGF-1 ratio confirming the diagnosis of NICH. Computed tomography (CT) of the abdomen showed a massive tumor of the liver consistent with hepatocellular carcinoma. Since the patient refused surgery, he was started on prednisone however the hypoglycemia persisted. A 54-year-old female patient with a history of type 2 diabetes mellitus (DM) admitted with recent onset hypoglycemia. Despite stopping her insulin, she continued to have hypoglycemia necessitating the administration of high concentrations of intravenous dextrose. Further evaluation showed low levels of insulin, C-peptide, and beta-hydroxybutyrate along with an elevated IGF-2/IGF-1 ratio consistent with the diagnosis of NICH. CT abdomen showed a 24 cm tumor near the uterus. The pathology was consistent with a gastrointestinal stromal tumor (GIST). After surgical excision of the tumor, the hypoglycemia resolved.
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