ArticleFrontiers in neurology2019
Disrupted White Matter Microstructure of the Cerebellar Peduncles in Scholastic Athletes After Concussion.
Article in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- The second decade of DTI in TBI part 1: a systematic review of mild TBI.Frontiers in neurologyPooled it
- A Diffusion Tensor Imaging Study: Relation of Wisconsin Card Sorting Covariates to White Matter Abnormalities in Traumatic Brain Injury.Life (Basel, Switzerland) · 2025Article
- Alterations of cerebrovascular reactivity following pediatric mild traumatic brain injury are independent of neurodevelopmental changes.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- The NERD model: reflex circuit dysfunction as a systems-level driver of persistent post-concussion symptoms.Frontiers in systems neuroscience · 2025Article
- Emotional Resilience Predicts Preserved White Matter Microstructure Following Mild Traumatic Brain Injury.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Article
- Dual statistical models link baseline visual attention measure to risk for significant symptomatic concussion in sports.Concussion (London, England) · 2023Article
- Multimodal magnetic resonance imaging of youth sport-related concussion reveals acute changes in the cerebellum, basal ganglia, and corpus callosum that resolve with recovery.Frontiers in human neuroscience · 2022Article
- Regional White Matter Diffusion Changes Associated with the Cumulative Tensile Strain and Strain Rate in Nonconcussed Youth Football Players.Journal of neurotrauma · 2021Article
- Potential Mechanisms of Acute Standing Balance Deficits After Concussions and Subconcussive Head Impacts: A Review.Annals of biomedical engineering · 2021Review
- Neuroimaging and advanced research techniques may lead to improved outcomes in military members suffering from traumatic brain injury.Trauma surgery & acute care open · 2021Review
- Eye movement performance and clinical outcomes among female athletes post-concussion.Brain injury · 2020Article
- Concussion Disrupts Normal Brain White Matter Microstructural Symmetry.Frontiers in neurology · 2020Article
- Altered Cerebellar White Matter in Sensory Processing Dysfunction Is Associated With Impaired Multisensory Integration and Attention.Frontiers in psychology · 2020Article
- Neuro-Inflammation in Pediatric Traumatic Brain Injury-from Mechanisms to Inflammatory Networks.Brain sciences · 2019Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Concussion, or mild traumatic brain injury (mTBI), is a major public health concern, linked with persistent post-concussive syndrome, and chronic traumatic encephalopathy. At present, standard clinical imaging fails to reliably detect traumatic axonal injury associated with concussion and post-concussive symptoms. Diffusion tensor imaging (DTI) is an MR imaging technique that is sensitive to changes in white matter microstructure. Prior studies using DTI did not jointly investigate white matter microstructure in athletes, a population at high risk for concussive and subconcussive head traumas, with those in typical emergency room (ER) patients. In this study, we determine DTI scalar metrics in both ER patients and scholastic athletes who suffered concussions and compared them to those in age-matched healthy controls. In the early subacute post-concussion period, athletes demonstrated an elevated rate of regional decreases in axial diffusivity (AD) compared to controls. These regional decreases of AD were especially pronounced in the cerebellar peduncles, and were more frequent in athletes compared to the ER patient sample. The group differences may indicate differences in the mechanisms of the concussive impacts as well as possible compound effects of cumulative subconcussive impacts in athletes. The prevalence of white matter abnormality in cerebellar tracts lends credence to the hypothesis that post-concussive symptoms are caused by shearing of axons within an attention network mediated by the cerebellum, and warrant further study of the correlation between cerebellar DTI findings and clinical, neurocognitive, oculomotor, and vestibular outcomes in mTBI patients.
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