Evidence map›Paper›PMID 31156468›Full record

ArticleFrontiers in physiology2019

Exercise and Conjugated Linoleic Acid Supplementation Induce Changes in the Composition of Liver Fatty Acids.

Adriana Mika, Aleksandra Czumaj, Piotr Stepnowski, Filippo Macaluso, Giulio Spinoso, Rosario Barone, Valentina Di Felice, Tomasz Sledzinski

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Adriana MikaDepartment of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Gdańsk, Gdańsk, Poland.
Aleksandra CzumajDepartment of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Gdańsk, Gdańsk, Poland.
Piotr StepnowskiDepartment of Environmental Analysis, Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland.
Filippo MacalusoDepartment of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy.
Giulio SpinosoDepartment of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy.
Rosario BaroneDepartment of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy.
Valentina Di FeliceDepartment of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy.
Tomasz SledzinskiDepartment of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Gdańsk, Gdańsk, Poland.
Gdańsk Medical University · PLIstituto Euro Mediterraneo di Scienza e Tecnologia · ITUniversity of Palermo · ITUniversity of Gdańsk · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exercise and supplementation with conjugated linoleic acid (CLA) are used to reduce body weight and to improve health. Applied together, they may exert a synergistic effect. However, the effects of exercise and CLA supplementation on liver metabolism are poorly understood. The aim of this study was to examine the influence of exercise and CLA supplementation on fatty acids (FA) composition in mouse liver. We analyzed 44 of known FAs of this organ by gas chromatography-mass spectrometry. Our results demonstrated that exercise contributed to a decrease in odd-chain FA and an increase in n-6 polyunsaturated FA contents. In turn, CLA stimulated an increase in branched-chain FAs and n-3 polyunsaturated FAs. Exercise combined with CLA supplementation caused a substantial increase in branched-chain FA content and a slight increase in n-6 polyunsaturated FAs. The elevated liver content of branched-chain FAs after the exercise combined with CLA supplementation, as well as the increase in n-3 polyunsaturated FAs after CLA may be favorable since both these FA groups were previously shown to produce health benefits. However, the expression pattern of enzymes involved in fatty acid synthesis did not match the changes in FA composition. Thus, the mechanism of exercise- and CLA-induced changes in liver FA profile is yet to be established. Also, the consequences of CLA- and/or exercise-induced changes in the composition of liver FAs need to be elucidated.

Indexed as

conjugated linoleic acidexercisefatty acidlivermyokine

Identifiers

PMID31156468
PMCPMC6529594
OpenAlexW2944990009

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.