Evidence map›Paper›PMID 31156375›Full record

ArticleFrontiers in neuroscience2019

Embelin, a Potent Molecule for Alzheimer's Disease: A Proof of Concept From Blood-Brain Barrier Permeability, Acetylcholinesterase Inhibition and Molecular Docking Studies.

Saatheeyavaane Bhuvanendran, Nur Aziah Hanapi, Nafees Ahemad, Iekhsan Othman, Siti Rafidah Yusof, Mohd Farooq Shaikh

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 28 citations in OpenAlex.

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  5. Quinones as Neuroprotective Agents.Antioxidants (Basel, Switzerland) · 2023
    Review
  6. Article
  7. Exploring the Chemical Profiles and Biological Values of TwoAntioxidants (Basel, Switzerland) · 2021
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Saatheeyavaane BhuvanendranNeuropharmacology Research Laboratory, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Malaysia.
Nur Aziah HanapiCentre for Drug Research, Universiti Sains Malaysia, Penang, Malaysia.
Nafees AhemadSchool of Pharmacy, Monash University Malaysia, Bandar Sunway, Malaysia.
Iekhsan OthmanNeuropharmacology Research Laboratory, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Malaysia.
Siti Rafidah YusofCentre for Drug Research, Universiti Sains Malaysia, Penang, Malaysia.
Mohd Farooq ShaikhNeuropharmacology Research Laboratory, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Malaysia.
Monash University Malaysia · MYUniversiti Sains Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Embelin is well-known in ethnomedicine and reported to have central nervous system activities. However, there is no report on blood-brain barrier (BBB) permeability of embelin. Here the BBB permeability of embelin was evaluated using

Indexed as

acetylcholinesterase inhibitoramyloid beta peptidesblood-brain barrierembelinmolecular dockingpermeability

Identifiers

PMID31156375
PMCPMC6532548
OpenAlexW2946260551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.