Evidence map›Paper›PMID 31156183›Full record

ArticleJournal of Parkinson's disease2019

Fatigue in Parkinson's Disease Associates with Lower Ambulatory Diastolic Blood Pressure.

Vikas Kotagal, Ashley Szpara, Roger L Albin, Nicolaas I Bohnen

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In one paragraph

Article in Journal of Parkinson's disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vikas KotagalDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Ashley SzparaDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Roger L AlbinDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Nicolaas I BohnenDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.

Funding

Public Outreach and Education CoreP50NS091856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 2014 to 2019
$10.1M
Cardiovascular Risk Factors and Rapid Disease Progression in Parkinson DiseaseIK2CX001186 · VA · VETERANS HEALTH ADMINISTRATION · PI KOTAGAL, VIKAS · 2016 to 2019
–
CSRD VA IK2 CX001186NINDS NIH HHS P50 NS091856
6 · The paper itself

Abstract

BACKGROUND/

objectiveFatigue is a common debilitating symptom in Parkinson's disease (PD) of unclear etiology. Hypotension and blood pressure variability are common in PD though their relationship to other non-motor symptoms is less well understood.

methodsWe conducted a cross-sectional study to explore differences in 24-hour ambulatory blood pressure measurements in PD subjects (n = 35) with and without fatigue. Subjects underwent hourly systolic (SBP) and diastolic (DBP) blood pressure testing in their home environment. The presence of fatigue was assessed using the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part 1. We compared blood pressure measurements in fatigued vs. non-fatigued PD subjects, assessed over 4 epochs: overnight, morning, midday, and evening.

resultsPD subjects with symptoms of fatigue demonstrated lower mean DBP, compared to those without fatigue (67.8±4.8 mmHg vs. 75.6±9.4 t = 2.57, p = 0.014). These intergroup differences were most notable in the morning. The two groups did not differ in scoring on the Survey of Autonomic Symptoms or on an office-based blood assessment of SBP or DBP performed on the day of 24-hour monitor initiation.

conclusionsFatigue in PD may be a clinical manifestation of low-grade systemic hypotension.

Indexed as

AgedAutonomic Nervous SystemBlood PressureBlood Pressure Monitoring, AmbulatoryCross-Sectional StudiesFatigueHumansHypotensionMaleMiddle AgedParkinson DiseaseAutonomic symptomsblood pressurefatiguehypotensionParkinson’s disease

Identifiers

PMID31156183
PMCPMC6682445

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.