ArticleDevelopment and psychopathology2019
Trait neuroticism and emotion neurocircuitry: Functional magnetic resonance imaging evidence for a failure in emotion regulation.
Article in Development and psychopathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Gray matter structures associated with neuroticism: A meta-analysis of whole-brain voxel-based morphometry studies.Human brain mapping · 2021Pooled it
- Neural Mechanisms of Neuroticism: Large-Scale Brain Networks, Developmental Trajectories, and Translational Implications.Brain sciences · 2026Review
- From anxiety and depression to non-suicidal self-injury in youths: the mediating effect of neuroticism and the moderating effect of thyroid hormones.Frontiers in psychiatry · 2026Article
- Who regulates when told? A systematic investigation of implicit to explicit emotion regulation.Frontiers in psychology · 2026Article
- Personality Trait Dimensions and Depressive Symptoms Among Medical Students: Sequential Mediation Through Psychological Capital and Perceived Stress.Depression and anxiety · 2026Article
- Stereo-Electroencephalography Reveals Dynamic Spatio-Spectral Signatures of Negative Emotions: A Distributed Circuit Mechanism Involving Amygdala-Cingulate-Hippocampus-Orbitofrontal Networks.Brain and behavior · 2025Article
- The functional neurobiology of negative affective traits across regions, networks, signatures, and a machine learning multiverse.bioRxiv : the preprint server for biology · 2025Article
- An Honest Reckoning With the Amygdala and Mental Illness.The American journal of psychiatry · 2024Review
- Neuroticism/Negative Emotionality Is Associated with Increased Reactivity to Uncertain Threat in the Bed Nucleus of the Stria Terminalis, Not the Amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Neuroticism/negative emotionality is associated with increased reactivity to uncertain threat in the bed nucleus of the stria terminalis, not the amygdala.bioRxiv : the preprint server for biology · 2024Article
- The relationship between personality traits and happiness: the mediating role of emotional regulation.BMC nursing · 2024Article
- The big five factors as differential predictors of self-regulation, achievement emotions, coping and health behavior in undergraduate students.BMC psychology · 2024Article
- Article
- Polygenic risk for neuroticism is associated with less efficient control in more difficult situations.Psychiatry research. Neuroimaging · 2023Article
- Association between Mood and Sensation Seeking Following rTMS.Brain sciences · 2023Article
- Brain-gut microbiome profile of neuroticism predicts food addiction in obesity: A transdiagnostic approach.Progress in neuro-psychopharmacology & biological psychiatry · 2023Article
- Intolerance of Uncertainty and Emotional Processing in Adolescence: Separating Between-Person Stability and Within-Person Change.Research on child and adolescent psychopathology · 2023Article
- Anxiety-Related Frontocortical Activity Is Associated With Dampened Stressor Reactivity in the Real World.Psychological science · 2022Article
- The Relation between Neuroticism and Non-Suicidal Self-Injury Behavior among College Students: Multiple Mediating Effects of Emotion Regulation and Depression.International journal of environmental research and public health · 2022Article
- Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): III. Emotional dysfunction superspectrum.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Though theory suggests that individual differences in neuroticism (a tendency to experience negative emotions) would be associated with altered functioning of the amygdala (which has been linked with emotionality and emotion dysregulation in childhood, adolescence, and adulthood), results of functional neuroimaging studies have been contradictory and inconclusive. We aimed to clarify the relationship between neuroticism and three hypothesized neural markers derived from functional magnetic resonance imaging during negative emotion face processing: amygdala activation, amygdala habituation, and amygdala-prefrontal connectivity, each of which plays an important role in the experience and regulation of emotions. We used general linear models to examine the relationship between trait neuroticism and the hypothesized neural markers in a large sample of over 500 young adults. Although neuroticism was not significantly associated with magnitude of amygdala activation or amygdala habituation, it was associated with amygdala-ventromedial prefrontal cortex connectivity, which has been implicated in emotion regulation. Results suggest that trait neuroticism may represent a failure in top-down control and regulation of emotional reactions, rather than overactive emotion generation processes, per se. These findings suggest that neuroticism, which has been associated with increased rates of transdiagnostic psychopathology, may represent a failure in the inhibitory neurocircuitry associated with emotion regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.