ArticleEpigenetics2019
Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts.
Open access · bronzeAbstract read
In one paragraph
Article in Epigenetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- A Meta-Analysis of Brain DNA Methylation Across Sex, Age, and Alzheimer's Disease Points for Accelerated Epigenetic Aging in Neurodegeneration.Frontiers in aging neuroscience · 2021Pooled it
- Comparative Analysis ofBiomedicines · 2026Article
- Embracing non-linearity in human ageing.Nature reviews. Genetics · 2026Review
- DNA Methylation Signatures of Cellular Senescence Are Not Reversed by Senolytic Treatment.Aging cell · 2026Article
- Retinal polyunsaturated fatty acid supplementation reverses aging-related vision decline in mice.Science translational medicine · 2025Article
- Asynchronous aging and turnover of human circulating and tissue-resident memory T cells across sites.Immunity · 2025Article
- Methylation levels in keratinocyte basal cells reflect donor age and associate with altered cellular proliferation pathways.Epigenomics · 2025Article
- Functionally enriched epigenetic clocks reveal tissue-specific discordant aging patterns in individuals with cancer.Communications medicine · 2025Article
- Review
- Monitoring Autophagy in Human Aging: Key Cell Models and Insights.Frontiers in bioscience (Landmark edition) · 2025Review
- What makes biological age epigenetic clocks tick.Nature aging · 2025Article
- Methylation and algorithms in biological aging: a scoping review.Frontiers in aging · 2025Review
- Multiomics of Aging and Aging-Related Diseases.International journal of molecular sciences · 2024Review
- Patient-specific responses toMolecular therapy. Methods & clinical development · 2024Article
- Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts.PLoS biology · 2024Article
- Unveiling the molecular landscape of cognitive aging: insights from polygenic risk scores, DNA methylation, and gene expression.Human genomics · 2024Article
- Polyunsaturated Fatty Acid - mediated Cellular Rejuvenation for Reversing Age-related Vision Decline.bioRxiv : the preprint server for biology · 2024Article
- An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivo.Genome medicine · 2024Article
- Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation.eLife · 2024Article
- Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 2 countries.
Gabriel Sturma Department of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center , New York , NY , USA.ORCID 0000-0002-7280-4310
Andres Cardenasb Division of Environmental Health Sciences, University of California, Berkeley, School of Public Health , Berkeley , CA , USA.ORCID 0000-0003-2284-3298
Marie-Abèle Bindc Department of Statistics, Harvard University , Cambridge , MA , USA.ORCID 0000-0002-0422-6651
Steve Horvathd Human Genetics, David Geffen School of Medicine, University of California Los Angeles , Los Angeles , CA , USA.ORCID 0000-0002-4110-3589
Shuang Wange Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center , New York , NY , USA.ORCID 0000-0002-1693-6888
Yunzhang Wangf Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Stockholm , Sweden.ORCID 0000-0003-1165-3595
Sara Häggf Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Stockholm , Sweden.ORCID 0000-0002-2452-1500
Michio Hiranog Department of Neurology, H. Houston Merritt Center, Columbia Translational Neuroscience Initiative, Columbia University Irving Medical Center , New York , NY , USA.ORCID 0000-0002-7070-7402
Martin Picarda Department of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center , New York , NY , USA.ORCID 0000-0003-2835-0478
Columbia University Irving Medical Center · USKarolinska Institutet · SEBerkeley Public Health Division · USColumbia University · USHarvard University · USUniversity of California, Los Angeles · US
Funding
THERAPEUTIC APPROACHES IN MODELS OF MITOCHONDRIAL DIS.P01HD032062 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DIMAURO, SALVATORE · 1995 to 2014
$24.4MThe North American Mitochondrial Disease Consortium (NAMDC)U54NS078059 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HIRANO, MICHIO · 2011 to 2023
$17.5MValidation and optimization of epigenetic clocksU01AG060908 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2018 to 2022
$3.4MTransduction of Psychological Stress into Systematic Inflammation by Mitochondrial DNA SignalingR01MH119336 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI KAUFMAN, BRETT A, MARSLAND, ANNA L · 2019 to 2023
$3.4MGENETIC &ENVIRONMENTAL INFLUENCES--BIOBEHAVIORAL AGINGR01AG010175 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PEDERSEN, NANCY L · 1992 to 2006
$2.8MDeep learning based predictive analytics to improve patient health.R01LM013061 · NLM · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Krzysztof Kiryluk, CHUNHUA WENG · 2019 to 2026
$2.7MTransporting established insights from classical experimental design to address causal questions in environmental epidemiology including the understanding of biological mediating mechanismsDP5OD021412 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI BIND, MARIE-ABELE CATHERINE · 2016 to 2020
$2.1MMitochondrial Stress Signal Transduction from Organelle to OrganismR35GM119793 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PICARD, MARTIN · 2016 to 2020
$1.6MCholesterol metabolism pathway: Cognitive change and Alzheimer's disease riskR01AG028555 · NIA · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI REYNOLDS, CHANDRA A · 2007 to 2010
$1.1MMitochondrial Regulation of Stress Reactivity in HumansR21MH113011 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PICARD, MARTIN · 2017 to 2018
$440kTherapeutic potential of enhanced mitochondrial biogenesis for paclitaxel-induced peripheral neuropathyR21CA226672 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HIRANO, MICHIO · 2018 to 2019
$378kNCI NIH HHS R21 CA226672NIA NIH HHS R01 AG010175NIA NIH HHS R01 AG028555NIA NIH HHS U01 AG060908NICHD NIH HHS P01 HD032062NIGMS NIH HHS R35 GM119793NIH HHS DP5 OD021412NIMH NIH HHS R01 MH119336NIMH NIH HHS R21 MH113011NINDS NIH HHS U54 NS078059NLM NIH HHS R01 LM013061
Abstract
Aging is associated with progressive and site-specific changes in DNA methylation (DNAm). These global changes are captured by DNAm clocks that accurately predict chronological age in humans but relatively little is known about how clocks perform
Indexed as
DNA MethylationDown-RegulationAdultAgingCell Culture TechniquesCells, CulturedCellular SenescenceCpG IslandsEpigenesis, GeneticFatty Acid ElongasesFibroblastsHumansMalePromoter Regions, GeneticELOVL2 protein, humanFatty Acid Elongasesaccelerated agingAgingDNA methylationepigenetic agelifespanprimary culture
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.