ArticleThoracic cancer2019
Risk factors associated with an increase in the size of ground-glass lung nodules on chest computed tomography.
Article in Thoracic cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk factors for the growth of ground-glass nodules in the lungs: A systematic review and meta-analysis.Clinics (Sao Paulo, Brazil) · 2025Pooled it
- Exploring the risk factors for the growth of pure ground-glass nodules in a 3-year follow-up period.Quantitative imaging in medicine and surgery · 2025Article
- Predicting malignant risk of ground-glass nodules using convolutional neural networks based on dual-time-pointCancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- Tumor blood vessel in 3D reconstruction CT imaging as an risk indicator for growth of pulmonary nodule with ground-glass opacity.Journal of cardiothoracic surgery · 2023Article
- The natural growth history of persistent pulmonary subsolid nodules: Radiology, genetics, and clinical management.Frontiers in oncology · 2022Review
- Using a risk model for probability of cancer in pulmonary nodules.Thoracic cancer · 2021Article
- Natural history of pathologically confirmed pulmonary subsolid nodules with deep learning-assisted nodule segmentation.European radiology · 2021Article
- Implications of the updated Lung CT Screening Reporting and Data System (Lung-RADS version 1.1) for lung cancer screening.Journal of thoracic disease · 2020Review
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10 authors.
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Abstract
backgroundThe detection rate of ground-glass nodules (GGNs) in the lung has increased with the increased use of low-dose computed tomography (CT) of the chest for cancer screening; however, limited data is available on the natural history, follow-up, and treatment of GGNs. The aim of this study was to identify factors associated with an increase in the size of GGNs.
methodsA total of 338 patients (mean ages, 59.8 years; males, 35.5%) with 689 nodules who underwent chest CT at our institute between June 2004 and February 2014 were included in this study. The cut-off date of follow-up was August 2018. We analyzed the size, solidity, number, and margins of the nodules compared with their appearance on previous chest CT images. The Cox proportional hazard model was used to identify risk factors associated with nodule growth.
resultsThe median follow-up period was 21.8 months. Of the 338 patients, 38.5% had a history of malignancy, including lung cancer (8.9%). Among the 689 nodules, the median size of the lesions was 6.0 mm (IQR, 5-8 mm), and the proportion of nodules with size ≥10 mm and multiplicity was 17.1% and 66.3%, respectively. Compared to the nodules without an increase in size, the 79 nodules with an increase in size during the follow-up period were initially larger (growth group, 7.0 mm vs. non-growth group, 6.0 mm; P = 0.027), more likely to have a size ≥10 mm (26.6% vs. 15.9%; P = 0.018), and had less frequent multiplicity (54.4% vs. 67.9%, P = 0.028). In the multivariate analysis, nodule size ≥10 mm (hazard ratio [HR], 2.044; P = 0.005), a patient history of lung cancer (HR: 2.190, P = 0.006), and solitary nodule (HR: 2.499, P < 0.001) were independent risk factors for nodule growth.
conclusionCareful follow-up of GGNs is warranted in patients with a history of malignancy, a large , or a solitary nodule.
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