ArticleAnnals of neurology2019
Early electroencephalography for outcome prediction of postanoxic coma: A prospective cohort study.
Article in Annals of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 5 of them syntheses that pooled it.
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Who cites it
72 citing papers in PubMed, 5 syntheses or guidelines pooled it, 188 citations in OpenAlex.
- 2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 6. Post-cardiac arrest care.Clinical and experimental emergency medicine · 2026Guideline
- European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2025: post-resuscitation care.Intensive care medicine · 2025Guideline
- Predicting Long-Term Cognitive Impairments in Survivors after Cardiac Arrest: A Systematic Review.Journal of rehabilitation medicine · 2023Pooled it
- 2020 Korean Guidelines for Cardiopulmonary Resuscitation. Part 5. Post-cardiac arrest care.Clinical and experimental emergency medicine · 2021Guideline
- Prediction of poor neurological outcome in comatose survivors of cardiac arrest: a systematic review.Intensive care medicine · 2020Pooled it
- Unreactive EEG Background Is Associated With Unfavorable Outcome in Patients With Disorders of Consciousness of Various Etiologies: An Adult Cohort Study.European journal of neurology · 2025Trial
- Early risk stratification for progression to death by neurological criteria following out-of-hospital cardiac arrest.Resuscitation · 2022Trial
- Trial
- Prognostic Significance of EEG Patterns in Post-Cardiac Arrest Coma: A Multicenter Retrospective Cohort Study of 1,000 Patients.Neurology open access · 2026Article
- Role of Neurophysiologic Testing in Prognostication of Hypoxic-Ischemic Encephalopathy.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2026Review
- Rhythmic and Periodic Patterns and Seizures in Hypoxic-Ischemic Encephalopathy.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2026Review
- (f)Utility of cEEG after cardiac arrest should not be judged by its unique prognostic contribution.Critical care (London, England) · 2026Article
- Electroencephalogram Monitoring in Critical Care: Multicenter Analysis of Timing, Duration, and Readmissions.Critical care explorations · 2026Article
- Reply to: Utility in prognostication of continuous EEG monitoring in postanoxic coma: finding the right balance.Critical care (London, England) · 2026Article
- Changes in diagnostic and care trajectories following use of continuous EEG monitoring for neuroprognostication after out of hospital cardiac arrest - a before-and-after study.Resuscitation plus · 2026Article
- [Neurological prognosis after cardiac arrest and resuscitation].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026Review
- Prognostic assessment of comatose patients after cardiac arrest: construction of a simplified monitoring EEG risk score across different time windows.Frontiers in neurology · 2026Article
- Utility of continuous EEG monitoring in postanoxic coma: a retrospective multicenter study.Critical care (London, England) · 2025Article
- Pediatric cardiac arrest outcome prediction using data-driven machine learning of early quantitative electroencephalogram (qEEG) features.Resuscitation · 2025Article
- Early EEG and serum biomarkers for prognostication after cardiac arrest.Resuscitation plus · 2025Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveTo provide evidence that early electroencephalography (EEG) allows for reliable prediction of poor or good outcome after cardiac arrest.
methodsIn a 5-center prospective cohort study, we included consecutive, comatose survivors of cardiac arrest. Continuous EEG recordings were started as soon as possible and continued up to 5 days. Five-minute EEG epochs were assessed by 2 reviewers, independently, at 8 predefined time points from 6 hours to 5 days after cardiac arrest, blinded for patients' actual condition, treatment, and outcome. EEG patterns were categorized as generalized suppression (<10 μV), synchronous patterns with ≥50% suppression, continuous, or other. Outcome at 6 months was categorized as good (Cerebral Performance Category [CPC] = 1-2) or poor (CPC = 3-5).
resultsWe included 850 patients, of whom 46% had a good outcome. Generalized suppression and synchronous patterns with ≥50% suppression predicted poor outcome without false positives at ≥6 hours after cardiac arrest. Their summed sensitivity was 0.47 (95% confidence interval [CI] = 0.42-0.51) at 12 hours and 0.30 (95% CI = 0.26-0.33) at 24 hours after cardiac arrest, with specificity of 1.00 (95% CI = 0.99-1.00) at both time points. At 36 hours or later, sensitivity for poor outcome was ≤0.22. Continuous EEG patterns at 12 hours predicted good outcome, with sensitivity of 0.50 (95% CI = 0.46-0.55) and specificity of 0.91 (95% CI = 0.88-0.93); at 24 hours or later, specificity for the prediction of good outcome was <0.90.
interpretationEEG allows for reliable prediction of poor outcome after cardiac arrest, with maximum sensitivity in the first 24 hours. Continuous EEG patterns at 12 hours after cardiac arrest are associated with good recovery. ANN NEUROL 2019;86:203-214.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.