Trial reportHistopathology2019
Reproducibility of lymphovascular space invasion (LVSI) assessment in endometrial cancer.
Trial report in Histopathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed.
- Reproducibility of lymphovascular space invasion (LVSI) assessment in endometrial cancer.Histopathology · 2019Trial
- Molecular Profile of Advanced Endometrial Cancer (FIGO III-IV) in a Polish Multicentre Cohort: Clinicopathological Characterisation and Treatment Implications.Journal of clinical medicine · 2026Article
- Association of immunohistochemically defined molecular subtypes with substantial lymphovascular space invasion in early-stage endometrial cancer: a single-center cohort of 575 patients.Journal of gynecologic oncology · 2026Article
- Substantial LVSI Is Independently Associated with Para-Aortic Nodal Metastasis in Patients Undergoing Laparoscopic Surgical Staging for Endometrial Cancer.Current oncology (Toronto, Ont.) · 2026Article
- Clinical application value of the updated FIGO 2023 classification compared with FIGO 2009 for endometrial cancer staging in a Chinese cohort.Journal of gynecologic oncology · 2026Article
- Radiomics nomogram from multiparametric magnetic resonance imaging for preoperative prediction of substantial lymphovascular space invasion in endometrial cancer.Abdominal radiology (New York) · 2026Article
- Impact of the 2023 FIGO staging system on risk stratification in endometrial cancer: a retrospective cohort study.World journal of surgical oncology · 2026Article
- Clinicopathological and Molecular Characterization of High Grade Endometrial Carcinomas of No Specific Molecular Profile (NSMP) Stratified by ER Status.International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2026Article
- Ultrasound based radiomics nomogram combined with clinical parameters to predict lymphovascular space invasion in endometrioid adenocarcinoma.Scientific reports · 2025Article
- Additional Risk Factors Lead to a Measurable Inflammatory Response in Stage I Endometrial Cancer-A Prospective Multicentric Observational Study.Indian journal of surgical oncology · 2025Article
- A comprehensive magnetic resonance imaging-based model for predicting lymphovascular space invasion in endometrial cancer: a retrospective observational study.Quantitative imaging in medicine and surgery · 2025Article
- Cancer of the corpus uteri: A 2025 update.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Review
- New histopathological and molecular findings in gynecological cancers.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Review
- The past, present, and future of FIGO staging of endometrial cancer.Journal of gynecologic oncology · 2025Review
- Effect of substantial lymphovascular space invasion on location of first disease recurrence in surgical stage I endometrioid endometrial adenocarcinoma.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2025Article
- Does FIGO 2023 meet clinical needs? An analysis of challenges and limitations.Przeglad menopauzalny = Menopause review · 2025Review
- Analysis of Differences in the Classification of Endometrial Cancer Patients in Poland.Cancers · 2025Article
- Predicting lymphovascular space invasion in early-stage cervical squamous cell carcinoma using heart rate variability.Frontiers in oncology · 2025Article
- Practical guidance for assessing and reporting lymphovascular space invasion (LVSI) in endometrial carcinoma.Histopathology · 2025Review
- SIR-EN-New Biomarker for Identifying Patients at Risk of Endometrial Carcinoma in Abnormal Uterine Bleeding at Menopause.Cancers · 2024Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
aimsLymphovascular space invasion (LVSI) in endometrial cancer (EC) is an important prognostic variable impacting on a patient's individual recurrence risk and adjuvant treatment recommendations. Recent work has shown that grading the extent of LVSI further improves its prognostic strength in patients with stage I endometrioid EC. Despite this, there is little information on the reproducibility of LVSI assessment in EC. Therefore, we designed a study to evaluate interobserver agreement in discriminating true LVSI from LVSI mimics (Phase I) and reproducibility of grading extent of LVSI (Phase II). METHODS AND
resultsScanned haematoxylin and eosin (H&E) slides of endometrioid EC (EEC) with a predefined possible LVSI focus were hosted on a website and assessed by a panel of six European gynaecological pathologists. In Phase I, 48 H&E slides were included for LVSI assessment and in Phase II, 42 H&E slides for LVSI grading. Each observer was instructed to apply the criteria for LVSI used in daily practice. The degree of agreement was measured using the two-way absolute agreement average-measures intraclass correlation coefficient (ICC). Reproducibility of LVSI assessment (ICC = 0.64, P < 0.001) and LVSI grading (ICC = 0.62, P < 0.001) in EEC was substantial among the observers.
conclusionsGiven the good reproducibility of LVSI, this study further supports the important role of LVSI in decision algorithms for adjuvant treatment.
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