ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2019
How Multiple Retrievals Affect Neural Reactivation in Young and Older Adults.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Neural correlates and reinstatement of recent and remote memory in children and young adults.eLife · 2025Article
- Effects of cortical thickness, volume, and memory performance on age differences in neural reinstatement of scene information.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Dissociative Effects of Age on Neural Differentiation at the Category and Item Levels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Age differences in neural distinctiveness during memory encoding, retrieval, and reinstatement.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Remembering past challenges to feel better today: Role of neural dedifferentiation and autobiographical integration in late-life reappraisal.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2022Review
- Age-related neural dedifferentiation for individual stimuli: an across-participant pattern similarity analysis.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2022Article
- The Retrieval-Related Anterior Shift Is Moderated by Age and Correlates with Memory Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Effects of age on goal-dependent modulation of episodic memory retrieval.Neurobiology of aging · 2021Article
- Age Differences In Retrieval-Related Reinstatement Reflect Age-Related Dedifferentiation At Encoding.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Age-related neural dedifferentiation and cognition.Current opinion in behavioral sciences · 2020Article
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Abstract
objectivesAging can reduce the specificity with which memory episodes are represented as distributed patterns of brain activity. It remains unclear, however, whether repeated encoding and retrieval of stimuli modulate this decline. Memory repetition is thought to promote semanticization, a transformative process during which episodic memory becomes gradually decontextualized and abstracted. Because semantic memory is considered more resilient to aging than context-rich episodic memory, we hypothesized that repeated retrieval would affect cortical reinstatement differently in young versus older adults.
methodsWe reanalyzed data from young and older adults undergoing functional magnetic resonance imaging while repeatedly viewing and recalling short videos. We derived trial-unique multivariate measures of similarity between video-specific brain activity patterns elicited at perception and at recall, which we compared between age groups at each repetition.
resultsWith repetition, memory representation became gradually more distinct from perception in young adults, as reinstatement specificity converged downward toward levels observed in the older group. In older adults, alternative representations that were item-specific but orthogonal to patterns elicited at perception became more salient with repetition. DISCUSSION: Repetition transformed dominant patterns of memory representation away and orthogonally from perception in young and older adults, respectively. Although distinct, both changes are consistent with repetition-induced semanticization.
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