Evidence map›Paper›PMID 31155658›Full record

ArticleAmerican journal of epidemiology2019

The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies.

Bing Yu, Krista A Zanetti, Marinella Temprosa, Demetrius Albanes, Nathan Appel, Clara Barrios Barrera, Yoav Ben-Shlomo, Eric Boerwinkle, Juan P Casas, Clary Clish and 64 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02328677 (ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis), which is not on this map. Cited by 74 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02328677 recruitingnot on this map

ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis

TypeobservationalSponsorUniversity of UtahRan2007 to 2030Enrolled5,000ConditionsColorectal Cancer
3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Metabolomic profiling reveals distinct and shared biology in COPD and IPF.Metabolomics : Official journal of the Metabolomic Society · 2026
    Article
  6. Review
  7. Impact of Daily Rhythms and Postprandial Responses on the Plasma Metabolome.International journal of molecular sciences · 2026
    Article
  8. Review
  9. Article
  10. Metabolite names and identifiers: how far are we from interoperability?Metabolomics : Official journal of the Metabolomic Society · 2026
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Application of Metabolomics across the Spectrum of Pulmonary and Critical Care Medicine.American journal of respiratory cell and molecular biology · 2024
    Review
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

74 authors.

Bing YuDepartment of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas.
Krista A ZanettiEpidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, Maryland.
Marinella TemprosaDepartment of Epidemiology and Biostatistics Milken Institute School of Public Health, George Washington University, Washington, DC.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Nathan AppelInformation Management Services, Inc., Rockville, Maryland.
Clara Barrios BarreraDepartment of Nephrology, Hospital del Mar, Institut Mar d´Investigacions Mediques, Barcelona, Spain.
Yoav Ben-ShlomoPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Eric BoerwinkleDepartment of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas.
Juan P CasasInstitute of Health Informatics Research, UCL Institute of Health Informatics, University College London, London, United Kingdom.
Clary ClishBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts.
Caroline DaleInstitute of Health Informatics Research, UCL Institute of Health Informatics, University College London, London, United Kingdom.
Abbas DehghanMedical Research Council-Public Health England Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Andriy DerkachDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
A Heather EliassenChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Paul ElliottMedical Research Council-Public Health England Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Eoin FahyDepartment of Bioengineering, School of Engineering, University of California, San Diego, La Jolla, California.
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Marc J GunterSection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
Sei HaradaDepartment of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan.
Tamara HarrisLaboratory of Epidemiology and Population Science Laboratory.
Deron R HerrDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
David HerringtonDepartment of Internal Medicine, Division of Cardiology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Joel N HirschhornBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts.
Elise HooverEpidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, Maryland.
Ann W HsingStanford Prevention Research Center, Stanford Cancer Institute, Stanford, California.
Mattias JohanssonInternational Agency for Research on Cancer, Lyon, France.
Rachel S KellySystems Genetics and Genomics Unit, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Chin Meng KhooDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Mika KivimäkiDepartment of Epidemiology and Public Health, University College London, London, United Kingdom.
Bruce S KristalDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Jessica Lasky-SuChanning Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Deborah A LawlorPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Luca A LottaMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
Loïc Le MarchandUniversity of Hawaii Cancer Center, Epidemiology Program, Honolulu, Hawaii.
Ewy MathéDepartment of Biomedical Informatics, College of Medicine, Ohio State University, Columbus, Ohio.
Charles E MatthewsDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Cristina MenniDepartment of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
Lorelei A MucciChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Rachel MurphyFaculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Matej OresicTurku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
Eric OrwollDepartment of Medicine, Oregon Health and Science University, Portland, Oregon.
Jennifer OseDivision of Cancer Population Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.
Alexandre C PereiraInstituto de Pesquisas Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Brazil.
Mary C PlaydonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Lucilla PostonDepartment of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, St. Thomas' Hospital, London, United Kingdom.
Jackie PriceUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Qibin QiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York.
Kathryn RexrodeDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Adam RischInformation Management Services, Inc., Rockville, Maryland.
Joshua SampsonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Wei Jie SeowSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Howard D SessoDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston Massachusetts.
Svati H ShahDepartment of Medicine, Duke University School of Medicine, Durham, North Carolina.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
Gordon C S SmithDepartment of Obstetrics and Gynaecology, National Institute for Health Research, Cambridge Comprehensive Biomedical Research Center, University of Cambridge, Cambridge, United Kingdom.
Ulla SovioCenter for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Victoria L StevensDepartment of Obstetrics and Gynaecology, University of Cambridge, National Institute for Health Research Cambridge Comprehensive Biomedical Research Centre, Cambridge, United Kingdom.
Rachael Stolzenberg-SolomonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Toru TakebayashiDepartment of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan.
Therese TillinInstitute of Cardiovascular Sciences, University College London, London, United Kingdom.
Ruth TravisCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Ioanna TzoulakiMedical Research Council-Public Health England Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Cornelia M UlrichDivision of Cancer Population Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.
Ramachandran S VasanSection of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts.
Mukesh VermaEpidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, Maryland.
Ying WangDepartment of Obstetrics and Gynaecology, University of Cambridge, National Institute for Health Research Cambridge Comprehensive Biomedical Research Centre, Cambridge, United Kingdom.
Nick J WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Andrew WongMRC Unit for Lifelong Health and Ageing at University College London, London, United Kingdom.
Naji YounesDepartment of Epidemiology and Biostatistics Milken Institute School of Public Health, George Washington University, Washington, DC.
Hua ZhaoDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
Steven C MooreDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.

Funding

PRIMARY PREVENTION TRIAL--DATA COORDINATING CENTERU01DK048489 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI JABLONSKI, KATHLEEN ANN, TEMPROSA, MARINELLA · 1994 to 2021
$84.8M
Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Women's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7M
WOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6M
Women's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5M
WOMEN'S INTERAGENCY HIV STUDY (WIHS) ORGANIZATION AND MANAGEMENTU01AI034994 · NIAID · GEORGETOWN UNIVERSITY · PI KASSAYE, SEBLE G · 1993 to 2018
$52.0M
Women's Interagency HIV Study (WIHS) IV, Chicago ConsortiumU01AI034993 · NIAID · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI COHEN, MARDGE H, FRENCH, AUDREY · 1994 to 2018
$51.0M
WOMENS INTERAGENCY HIV STUDY (WIHS)U01HD032632 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MILAM, JOEL E · 1994 to 2012
$42.0M
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
British Heart Foundation CS/13/1/30327British Heart Foundation CS/16/4/32482British Heart Foundation RG/10/12/28456British Heart Foundation SP/07/001/23603Cancer Research UK 14136Cancer Research UK 19170Cancer Research UK C570/A16491Department of Health RP-PG-0407-10452Medical Research Council 1000143Medical Research Council G0401527Medical Research Council G0500877Medical Research Council G1000143Medical Research Council G1001357Medical Research Council G1100221Medical Research Council MC_PC_13046Medical Research Council MC_PC_13048Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12019/1Medical Research Council MR/L00002/1Medical Research Council MR/L002477/1Medical Research Council MR/L01341X/1Medical Research Council MR/L01632X/1Medical Research Council MR/M012190/1Medical Research Council MR/N003284/1Medical Research Council MR/R023484/1Medical Research Council MR/R024227/1Medical Research Council MR/S011676/1NCATS NIH HHS U54 TR001012NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR000128NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1 TR002369NCI NIH HHS K07 CA140790NCI NIH HHS P01 CA087969NCI NIH HHS P01 CA168530NCI NIH HHS P50 CA090381NCI NIH HHS R01 CA034944NCI NIH HHS R01 CA040360NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA050385NCI NIH HHS R01 CA067262NCI NIH HHS R01 CA082729NCI NIH HHS R01 CA097193NCI NIH HHS R01 CA163451NCI NIH HHS R37 CA070867NCI NIH HHS U01 CA049449NCI NIH HHS U01 CA067262NCI NIH HHS U01 CA164973NCI NIH HHS U01 CA167552NCI NIH HHS U01 CA176726NCI NIH HHS U01 CA206110NCI NIH HHS UM1 CA164920NCI NIH HHS UM1 CA173640NCI NIH HHS UM1 CA176726NCI NIH HHS UM1 CA182910NCI NIH HHS UM1 CA186107NCRR NIH HHS M01 RR016587NHGRI NIH HHS U01 HG004402NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201300008CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS K01 HL129892NHLBI NIH HHS K01 HL146980NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HR016044NHLBI NIH HHS P01 HL132825NHLBI NIH HHS R01 HL026490NHLBI NIH HHS R01 HL034595NHLBI NIH HHS R01 HL036310NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL079123NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL095987NHLBI NIH HHS R01 HL111362NHLBI NIH HHS R01 HL123915NHLBI NIH HHS R01 HL127009NHLBI NIH HHS R01 HL133932NHLBI NIH HHS R01 HL141826NHLBI NIH HHS R56 HL129880NHLBI NIH HHS U01 HL091528NIAID NIH HHS P30 AI050410NIAID NIH HHS U01 AI031834NIAID NIH HHS U01 AI034989NIAID NIH HHS U01 AI034993NIAID NIH HHS U01 AI034994NIAID NIH HHS U01 AI035004NIAID NIH HHS U01 AI042590NIAID NIH HHS U01 AI103390NIAID NIH HHS U01 AI103397NIAID NIH HHS U01 AI103401NIAID NIH HHS U01 AI103408NIAMS NIH HHS R01 AR049880NIAMS NIH HHS U01 AR066160NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG013196NIA NIH HHS R01 AG028050NIA NIH HHS R01 AG034454NIA NIH HHS R56 AG056477NIA NIH HHS U01 AG027810NIA NIH HHS U01 AG042124NIA NIH HHS U01 AG042139NIA NIH HHS U01 AG042140NIA NIH HHS U01 AG042143NIA NIH HHS U01 AG042145NIA NIH HHS U01 AG042168NICHD NIH HHS U01 HD032632NIDDK NIH HHS K01 DK103720NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK040561NIDDK NIH HHS R01 DK075787NIDDK NIH HHS R01 DK078907NIDDK NIH HHS R01 DK081572NIDDK NIH HHS R01 DK103246NIDDK NIH HHS R01 DK108159NIDDK NIH HHS U01 DK048339NIDDK NIH HHS U01 DK048349NIDDK NIH HHS U01 DK048375NIDDK NIH HHS U01 DK048377NIDDK NIH HHS U01 DK048381NIDDK NIH HHS U01 DK048397NIDDK NIH HHS U01 DK048400NIDDK NIH HHS U01 DK048406NIDDK NIH HHS U01 DK048407NIDDK NIH HHS U01 DK048412NIDDK NIH HHS U01 DK048413NIDDK NIH HHS U01 DK048434NIDDK NIH HHS U01 DK048437NIDDK NIH HHS U01 DK048443NIDDK NIH HHS U01 DK048468NIDDK NIH HHS U01 DK048485NIDDK NIH HHS U01 DK048489NIDDK NIH HHS U01 DK048514NINDS NIH HHS R01 NS045893NINDS NIH HHS R01 NS089619NINR NIH HHS R01 NR012459Wellcome TrustWellcome Trust 102215/2/13/2Wellcome Trust 206046/Z/17/ZWellcome Trust WT082464Wellcome Trust WT092830/Z/10/ ZWorld Health Organization 001
6 · The paper itself

Abstract

The Consortium of Metabolomics Studies (COMETS) was established in 2014 to facilitate large-scale collaborative research on the human metabolome and its relationship with disease etiology, diagnosis, and prognosis. COMETS comprises 47 cohorts from Asia, Europe, North America, and South America that together include more than 136,000 participants with blood metabolomics data on samples collected from 1985 to 2017. Metabolomics data were provided by 17 different platforms, with the most frequently used labs being Metabolon, Inc. (14 cohorts), the Broad Institute (15 cohorts), and Nightingale Health (11 cohorts). Participants have been followed for a median of 23 years for health outcomes including death, cancer, cardiovascular disease, diabetes, and others; many of the studies are ongoing. Available exposure-related data include common clinical measurements and behavioral factors, as well as genome-wide genotype data. Two feasibility studies were conducted to evaluate the comparability of metabolomics platforms used by COMETS cohorts. The first study showed that the overlap between any 2 different laboratories ranged from 6 to 121 metabolites at 5 leading laboratories. The second study showed that the median Spearman correlation comparing 111 overlapping metabolites captured by Metabolon and the Broad Institute was 0.79 (interquartile range, 0.56-0.89).

Indexed as

Global HealthAdolescentAdultAgedAged, 80 and overBiomarkersBody Mass IndexChildEpidemiologic MethodsEpidemiologyFemaleHealth BehaviorHematologic TestsHumansLongitudinal StudiesMaleBiomarkerscancercohortdiabetesgeneticsheart diseasemetabolomicsprospective

Identifiers

PMID31155658
PMCPMC6545286

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