Evidence map›Paper›PMID 31155428›Full record

ArticleTrends in microbiology2019

Ebola Virus Replication Stands Out.

Wenjie Wang, Chao Wu, Gaya K Amarasinghe, Daisy W Leung

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Wenjie WangDepartment of Pathology and Immunology, Washington University School of Medicine in St Louis, St Louis, MO 63110, USA.
Chao WuDepartment of Pathology and Immunology, Washington University School of Medicine in St Louis, St Louis, MO 63110, USA.
Gaya K AmarasingheDepartment of Pathology and Immunology, Washington University School of Medicine in St Louis, St Louis, MO 63110, USA.
Daisy W LeungDepartment of Pathology and Immunology, Washington University School of Medicine in St Louis, St Louis, MO 63110, USA; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, MO 63110, USA. Electronic address: dwleung@wustl.edu.

Funding

Virology BSL4 CoreP01AI120943 · NIAID · WASHINGTON UNIVERSITY · PI Gaya K. Amarasinghe · 2016 to 2026
$30.2M
Novel VP30-host Interactions that Negatively Regulate Ebola Virus InfectionR01AI143292 · NIAID · WASHINGTON UNIVERSITY · PI AMARASINGHE, GAYA K., BASLER, CHRISTOPHER F · 2019 to 2023
$4.0M
Multi-platform High Throughput Screens for Filoviral Replication InhibitorsR01AI123926 · NIAID · WASHINGTON UNIVERSITY · PI AMARASINGHE, GAYA K. · 2016 to 2018
$2.1M
High-throughput screen for inhibitors of Marburg virus VP24-Keap1R01AI114654 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BASLER, CHRISTOPHER F · 2015 to 2017
$1.2M
NIAID NIH HHS P01 AI120943NIAID NIH HHS R01 AI114654NIAID NIH HHS R01 AI123926NIAID NIH HHS R01 AI143292
6 · The paper itself

Abstract

A recent study by Deflubé et al. (Proc. Natl. Acad. Sci. U. S. A. 2019;116:8535-8543) reported that Ebola virus genomes have variable 3' terminal nucleotides. This finding is a departure from other nonsegmented, negative-strand RNA viruses (NNSVs) that have been studied to date and has broad implications for filoviral replication and innate immune evasion.

Indexed as

Hemorrhagic Fever, EbolaEbolavirusGenome, ViralHumansImmune EvasionVirus ReplicationEbola virusinnate immune evasionreplication initiation

Identifiers

PMID31155428
PMCPMC6996267

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.