Evidence map›Paper›PMID 31155351›Full record

ArticleCurrent biology : CB2019

Cryptochromes-Mediated Inhibition of the CRL4

Luca Rizzini, Daniel C Levine, Mark Perelis, Joseph Bass, Clara B Peek, Michele Pagano

Open access · bronzeAbstract read
In one paragraph

Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Circadian NAD(P)(H) cycles in cell metabolism.Seminars in cell & developmental biology · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. IPNature communications · 2021
    Article
  13. Review
  14. Cancer, hear my battle CRY.Journal of pineal research · 2020
    Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Luca RizziniDepartment of Biochemistry and Molecular Pharmacology, Perlmutter NYU Cancer Center, New York University School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA. Electronic address: luca.rizzini@nyumc.org.
Daniel C LevineDivision of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Mark PerelisDivision of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Joseph BassDivision of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Clara B PeekDivision of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Michele PaganoDepartment of Biochemistry and Molecular Pharmacology, Perlmutter NYU Cancer Center, New York University School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA. Electronic address: michele.pagano@nyumc.org.
Northwestern University · USHoward Hughes Medical Institute · US

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1M
REGULATION OF THE GI PHASE BY THE UBIQUITIN PATHWAYR01GM057587 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PAGANO, MICHELE · 1998 to 2018
$7.8M
Integration of Feeding Time and Glucose Metabolism by the Circadian Gene NetworkR01DK090625 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH, LERNER, TALIA NEWCOMBE · 2011 to 2025
$6.9M
F-Box Proteins: Deregulated Cell Cycle Control and Proteolysis in CancerR01CA076584 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PAGANO, MICHELE · 1998 to 2021
$4.5M
Interplay of Dietary Lipid and Circadian Dysregulation in Metabolic SyndromeR01DK100814 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH · 2014 to 2018
$2.3M
Acquisition of an Orbitrap Elite Mass Spectrometer with ETDS10OD010582 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI UEBERHEIDE, BEATRIX MAGDALENA · 2013 to 2013
$600k
Circadian control of nutrient-sensing and fuel utilization in skeletal muscleK01DK105137 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PEEK, CLARA BIEN · 2015 to 2017
$331k
Coupling of muscle blind-dependent RNA processing to the circadian clock in neuronal homeostasis and sleepF32HL143978 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PERELIS, MARK · 2019 to 2021
$146k
Howard Hughes Medical InstituteNCI NIH HHS P30 CA016087NCI NIH HHS R01 CA076584NHLBI NIH HHS F32 HL143978NIDDK NIH HHS K01 DK105137NIDDK NIH HHS R01 DK090625NIDDK NIH HHS R01 DK100814NIGMS NIH HHS R01 GM057587NIH HHS S10 OD010582
6 · The paper itself

Abstract

In plants, cryptochromes are photoreceptors that negatively regulate the ubiquitin ligase CRL4

Indexed as

Signal TransductionAnimalsBiological EvolutionCell LineCryptochromesFemaleHEK293 CellsHumansIntracellular Signaling Peptides and ProteinsMaleMiceMice, Inbred C57BLNuclear ProteinsUbiquitin-Protein LigasesCOP1 protein, mouseCryptochromesDet1 protein, mouseIntracellular Signaling Peptides and ProteinsNuclear ProteinsUbiquitin-Protein Ligasescircadian clockc-JunCop1CRL4cryptochromesCul4Det1glucagonglucocorticoid receptortransrepression

Identifiers

PMID31155351
PMCPMC6581574
OpenAlexW2952417811

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.