ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2019
The role of mutation bias in adaptive molecular evolution: insights from convergent changes in protein function.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 75 citations in OpenAlex.
- Emergence Biases in Molecular Evolution.Genome biology and evolution · 2026Review
- Spontaneous mutation rate and spectrum are modulated by organismal fitness.Science advances · 2026Article
- Predicting the antigenic evolution of seasonal influenza viruses using phylogenetic convergence.bioRxiv : the preprint server for biology · 2026Article
- Module-Selection Balance in the Evolution of Modular Organisms.bioRxiv : the preprint server for biology · 2026Article
- Global Environmental Factors Impact the Evolution of Adult Hemoglobins in Squamata Reptiles (Lizards and Snakes) and Terrestrial Turtles.Genome biology and evolution · 2025Article
- Nonhypermutator Cancers Access Driver Mutations Through Reversals in Germline Mutational Bias.Molecular biology and evolution · 2025Article
- Genetic and Epigenetic Changes inLife (Basel, Switzerland) · 2025Article
- Quantitative trait loci concentrate in specific regions of the Mexican cavefish genome and reveal key candidate genes for cave-associated evolution.The Journal of heredity · 2025Article
- Convergent Evolution and Predictability of Gene Copy Numbers Associated with Diets in Mammals.Genome biology and evolution · 2025Article
- Loci associated with cave-derived traits concentrate in specific regions of the Mexican cavefish genome.bioRxiv : the preprint server for biology · 2024Article
- Shifts in Mutation Bias Promote Mutators by Altering the Distribution of Fitness Effects.The American naturalist · 2023Article
- Predicting evolutionary outcomes through the probability of accessing sequence variants.Science advances · 2023Article
- Eco-evolutionary trade-offs in the dynamics of prion strain competition.Proceedings. Biological sciences · 2023Article
- Shifts in mutation spectra enhance access to beneficial mutations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Mutation bias and the predictability of evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- High Nucleotide Diversity Accompanies Differential DNA Methylation in Naturally Diverging Populations.Molecular biology and evolution · 2023Article
- Towards evolutionary predictions: Current promises and challenges.Evolutionary applications · 2023Review
- Article
- Review
- Within-host genetic diversity of SARS-CoV-2 in the context of large-scale hospital-associated genomic surveillance.medRxiv : the preprint server for health sciences · 2022Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
An underexplored question in evolutionary genetics concerns the extent to which mutational bias in the production of genetic variation influences outcomes and pathways of adaptive molecular evolution. In the genomes of at least some vertebrate taxa, an important form of mutation bias involves changes at CpG dinucleotides: if the DNA nucleotide cytosine (C) is immediately 5' to guanine (G) on the same coding strand, then-depending on methylation status-point mutations at both sites occur at an elevated rate relative to mutations at non-CpG sites. Here, we examine experimental data from case studies in which it has been possible to identify the causative substitutions that are responsible for adaptive changes in the functional properties of vertebrate haemoglobin (Hb). Specifically, we examine the molecular basis of convergent increases in Hb-O
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