Evidence map›Paper›PMID 31154978›Full record

ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2019

Predictability in the evolution of Orthopteran cardenolide insensitivity.

Lu Yang, Nitin Ravikanthachari, Ricardo Mariño-Pérez, Riddhi Deshmukh, Mariana Wu, Adam Rosenstein, Krushnamegh Kunte, Hojun Song, Peter Andolfatto

Open access · bronzeAbstract read
In one paragraph

Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
10.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 51 citations in OpenAlex.

  1. Amino Acid Substitutions in the NaEcological entomology · 2026
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  4. Amino Acid Substitutions in the NabioRxiv : the preprint server for biology · 2025
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  12. Tissue-specific plant toxins and adaptation in a specialist root herbivore.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Identification of the NAJournal of chemical ecology · 2023
    Article
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Lu Yang1 Department of Ecology and Evolutionary Biology, Princeton University , Princeton, NJ 08544 , USA.
Nitin Ravikanthachari2 National Centre for Biological Sciences, Tata Institute of Fundamental Research , Bengaluru , India.
Ricardo Mariño-Pérez3 Department of Entomology, Texas A&M University , College Station, TX 77843 , USA.
Riddhi Deshmukh2 National Centre for Biological Sciences, Tata Institute of Fundamental Research , Bengaluru , India.
Mariana Wu1 Department of Ecology and Evolutionary Biology, Princeton University , Princeton, NJ 08544 , USA.
Adam Rosenstein1 Department of Ecology and Evolutionary Biology, Princeton University , Princeton, NJ 08544 , USA.
Krushnamegh Kunte2 National Centre for Biological Sciences, Tata Institute of Fundamental Research , Bengaluru , India.
Hojun Song3 Department of Entomology, Texas A&M University , College Station, TX 77843 , USA.
Peter Andolfatto4 Department of Biological Sciences, Columbia University , New York, NY 10027 , USA.
Princeton University · USTata Institute of Fundamental Research · INTexas A&M University · USColumbia University · US

Funding

Parallel evolution at Na,K-ATPase: a model system for understanding constraints on the evolution of novel protein functions.R01GM115523 · NIGMS · PRINCETON UNIVERSITY · PI ANDOLFATTO, PETER · 2015 to 2024
$2.8M
NIGMS NIH HHS R01 GM115523
6 · The paper itself

Abstract

The repeated evolutionary specialization of distantly related insects to cardenolide-containing host plants provides a stunning example of parallel adaptation. Hundreds of herbivorous insect species have independently evolved insensitivity to cardenolides, which are potent inhibitors of the alpha-subunit of Na

Indexed as

Insecticide ResistanceAmino Acid SequenceAnimalsBiological EvolutionCardenolidesHerbivoryInsectaInsecticidesInsect ProteinsOrthopteraPhylogenySequence AlignmentSodium-Potassium-Exchanging ATPaseCardenolidesInsecticidesInsect ProteinsSodium-Potassium-Exchanging ATPasecardenolideK+-ATPaseNa+Orthopteraparallel evolutionpleiotropytoxin insensitivity

Identifiers

PMID31154978
PMCPMC6560278
OpenAlexW2914857620

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.