Evidence map›Paper›PMID 31154667›Full record

ArticleInternational wound journal2019

End stage scurvy in the developed world: A diagnostic conundrum but not to be mistaken for pyoderma gangrenosum.

Stephanie T Le, Jenny Z Wang, Claire C Alexanian, Stephanie Y Johng, Forum B Patel, Elizabeth A Wang, Chelsea Ma, Reason Wilken, Michelle Y Cheng, Emanual Maverakis

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in International wound journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Pyoderma gangrenosum.Nature reviews. Disease primers · 2020
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Stephanie T LeDepartment of Dermatology, University of California, Davis, Sacramento, California.
Jenny Z WangDepartment of Dermatology, University of California, Davis, Sacramento, California.
Claire C AlexanianDepartment of Dermatology, University of California, Davis, Sacramento, California.ORCID https://orcid.org/0000-0002-0158-7718
Stephanie Y JohngGeorgetown University School of Medicine, Washington, District of Columbia.
Forum B PatelDepartment of Dermatology, University of California, Davis, Sacramento, California.
Elizabeth A WangDepartment of Dermatology, University of California, Davis, Sacramento, California.
Chelsea MaDepartment of Dermatology, University of California, Davis, Sacramento, California.
Reason WilkenDepartment of Dermatology, University of California, Davis, Sacramento, California.
Michelle Y ChengDepartment of Dermatology, University of California, Davis, Sacramento, California.
Emanual MaverakisDepartment of Dermatology, University of California, Davis, Sacramento, California.
University of California, Davis · USGeorgetown University · USAlbert Einstein College of Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Scurvy is a clinical syndrome, resulting from ascorbic acid deficiency. Prevalence of the condition is now extremely low in the Western population and its diagnosis can be challenging without a high index of suspicion. When cases do present, they are often misdiagnosed initially. Therefore, a thorough history, physical exam, and laboratory evaluation are key to showing this now rare but extremely well-known disease. We report a case of scurvy manifesting as persistent non-healing lower-extremity ulcerations, initially mistaken for pyoderma gangrenosum. The patient responded to appropriate replacement therapy, but ulcers were slow to heal. As was the case in our patient, symptom reversal may require additional nutritional replacement. We encourage physicians to consider nutritional deficiencies in their differential diagnoses and highlight the incidence of malnutrition in the proper clinical setting to avoid diagnostic delay.

Indexed as

AgedDelayed DiagnosisDermatologic AgentsDiagnosis, DifferentialFemaleHumansImmunotherapyInfliximabLeg UlcerPyoderma GangrenosumScurvyTreatment OutcomeWestern WorldDermatologic AgentsInfliximabascorbic acidpyoderma gangrenosumscurvyulcerswound healing

Identifiers

PMID31154667
PMCPMC7949452
OpenAlexW2947113264

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.