Evidence map›Paper›PMID 31154608›Full record

ArticleEndocrine2019

Fractalkine: an inflammatory chemokine elevated in subjects with polycystic ovary syndrome.

İsmail Demi R, Aslı Guler, Pınar Alarslan, Ahmet Murat Isil, Ozge Ucman, Behnaz Aslanipour, Mehmet Calan

Abstract read
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In one paragraph

Article in Endocrine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. The Disorders of Endometrial Receptivity in PCOS and Its Mechanisms.Reproductive sciences (Thousand Oaks, Calif.) · 2022
    Review
  8. Impairment of endometrial decidual reaction in early pregnant mice fed with high fat diet.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

İsmail Demi RDepartment of Internal Medicine, Izmir Bozyaka Training and Research Hospital, 35170, Bozyaka, Izmir, Turkey.
Aslı GulerDepartment of Family Physician, Izmir Bozyaka Training and Research Hospital, 35170, Bozyaka, Izmir, Turkey.
Pınar AlarslanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, 35170, Bozyaka, Izmir, Turkey.
Ahmet Murat IsilDepartment of Family Physician, Izmir Bozyaka Training and Research Hospital, 35170, Bozyaka, Izmir, Turkey.
Ozge UcmanDepartment of Family Physician, Izmir Bozyaka Training and Research Hospital, 35170, Bozyaka, Izmir, Turkey.
Behnaz AslanipourDepartment of Bioengineering, Faculty of Engineering, Ege University, 35100, Bornova, Izmir, Turkey.
Mehmet CalanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, 35170, Bozyaka, Izmir, Turkey. drmehmetcalan@gmail.com.
Izmir Bozyaka Eğitim ve Araştırma Hastanesi · TREge University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFractalkine (FKN) is an inflammatory chemokine related to reproductive system and glucose metabolism. There is a link between FKN and steroidogenesis as FKN induces progesterone synthesis. Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic disorder associated with low progesterone production and insulin resistance. We aimed to explore whether women with PCOS have any difference in FKN levels compared to women without PCOS. We also focused on determination of any association between FKN levels and hormonal-metabolic parameters in women with PCOS.

methodsThe current research was designed as a case-control study. Eighty subjects with PCOS and 80 age- and body mass index (BMI)-matched subjects with normal menstrual cycle were taken into the study. We measured circulating FKN levels via ELISA methods.

resultsCirculating FKN levels were higher in women with PCOS than controls (1.93 ± 0.61 vs. 1.22 ± 0.33 ng/ml, P< 0.001). FKN levels showed a positive correlation with body mass index (BMI), insulin resistance, inflammatory marker hs-CRP, total testosterone, and free-androgen index (FAI), whereas it showed a negative correlation with sex hormone-binding protein in women with PCOS. Linear regression analyses revealed that the link of FKN with BMI, insulin resistance, hs-CRP, and FAI was independent. Binary logistic regression analysis showed that the risk of having PCOS was associated with high levels of FKN.

conclusionsIncreased FKN levels related to insulin resistance, inflammation and androgens in women with PCOS. FKN may have an inter-related role in different pathophysiologic pathways of PCOS.

Indexed as

AdolescentAdultBody Mass IndexCase-Control StudiesChemokine CX3CL1FemaleHumansHyperandrogenismInflammationInflammation MediatorsInsulin ResistanceMiddle AgedPolycystic Ovary SyndromeTestosteroneUp-RegulationYoung AdultChemokine CX3CL1CX3CL1 protein, humanInflammation MediatorsTestosteroneBody mass indexFractalkineHyperandrogenismInflammationInsulin resistancePolycystic ovary syndrome

Identifiers

PMID31154608
OpenAlexW2947068142

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.