Evidence map›Paper›PMID 31154518›Full record

ArticleJournal of molecular modeling2019

Development of sodium glucose co-transporter 2 (SGLT2) inhibitors with novel structure by molecular docking and dynamics simulation.

Ruirui Feng, Lili Dong, Leng Wang, Yefei Xu, Huizhe Lu, Jianjun Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular modeling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ruirui FengDepartment of Applied Chemistry, College of Science, China Agricultural University, Beijing, 100193, China.
Lili DongDepartment of Applied Chemistry, College of Science, China Agricultural University, Beijing, 100193, China.
Leng WangDepartment of Applied Chemistry, College of Science, China Agricultural University, Beijing, 100193, China.
Yefei XuDepartment of Applied Chemistry, College of Science, China Agricultural University, Beijing, 100193, China.
Huizhe LuDepartment of Applied Chemistry, College of Science, China Agricultural University, Beijing, 100193, China. luhz@cau.edu.cn.
Jianjun ZhangDepartment of Applied Chemistry, College of Science, China Agricultural University, Beijing, 100193, China. 06001h@cau.edu.cn.

Funding

the National Nature Science Foundation of China 21172230the National Nature Science Foundation of China 21873115
6 · The paper itself

Abstract

In this study, molecular docking studies were carried out to explore the binding interactions of sodium glucose co-transporter 2 (SGLT2) with its inhibitors. A correlation between the docking scores and the experimental bioactivity was observed (R

Indexed as

Molecular Docking SimulationMolecular Dynamics SimulationBinding SitesDrug DiscoveryMolecular ConformationMolecular StructureProtein BindingQuantitative Structure-Activity RelationshipSodium-Glucose Transporter 2Sodium-Glucose Transporter 2 InhibitorsSodium-Glucose Transporter 2Sodium-Glucose Transporter 2 Inhibitors3D-QSARDecomposition free energy calculationFree energy calculationMolecular dockingMolecular dynamics simulationSGLT2

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.