Evidence map›Paper›PMID 31154461›Full record

ArticleExperimental brain research2019

Effect of early maternal separation stress on attention, spatial learning and social interaction behaviour.

Maltesh Y Kambali, Kumari Anshu, Bindu M Kutty, Ravi S Muddashetty, T Rao Laxmi

Abstract read
PubMed Publisher
In one paragraph

Article in Experimental brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
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  13. Differential regulation of innate immune system in frontal cortex and hippocampus in a "double-hit" neurodevelopmental model in rats.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
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  20. Oxytocin as an adolescent treatment for methamphetamine addiction after early life stress in male and female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Maltesh Y KambaliDepartment of Neurophysiology, National Institute of Mental Health and Neurosciences (NIMHANS), An Institute of National Importance (INI), Bengaluru, 560029, India.
Kumari AnshuDepartment of Neurophysiology, National Institute of Mental Health and Neurosciences (NIMHANS), An Institute of National Importance (INI), Bengaluru, 560029, India.
Bindu M KuttyDepartment of Neurophysiology, National Institute of Mental Health and Neurosciences (NIMHANS), An Institute of National Importance (INI), Bengaluru, 560029, India.
Ravi S MuddashettyinStem, National Centre for Biological Sciences (NCBS), GKVK Campus, Bengaluru, 560065, India.
T Rao LaxmiDepartment of Neurophysiology, National Institute of Mental Health and Neurosciences (NIMHANS), An Institute of National Importance (INI), Bengaluru, 560029, India. trlaxmi.nimhans@nic.in.
National Institute of Mental Health and Neurosciences · INNational Centre for Biological Sciences · IN

Funding

Indian Council of Medical Research ID 2012-02300Indian Council of Medical Research no.:55/03/2012-PHY/BMS
6 · The paper itself

Abstract

Early life stress is known to influence affective and cognitive functions in later life but comprehensive explanation for the impact of early life stress on attentional functions, behavioural control and social behaviour is inadequate. The early life stress was induced by exposing rat pups to 6 h of maternal separation and isolation (MS) stress from postnatal days 4-14 i.e. during SHRP period. The long-term impact of MS in these rats was evaluated by assessing anxiety, sociability, social preference, spatial learning and memory along with a detailed evaluation of attentional functions during young adulthood period. Adult male MS rats showed increased anxiety-like behaviour, impaired flexibility in social interactions, and increased reward-seeking behaviour. MS rats also showed faster spatial learning in the partially baited radial arm maze and exhibited moderately enhanced sustained attention in the 5-choice serial reaction time task (5CSRTT). These results suggest that early MS has both positive and negative consequences in adulthood. Increased cognitive ability in MS rats, as evidenced by the improved sustained attention and spatial learning and memory, is usually advantageous and indicates positive influences of early stressors that might lead to the development of resilience and enhanced compensatory mechanisms later in adulthood. MS stress has compromised flexibility in social behaviour that promotes solitary lifestyle and social isolation. Heightened reward-seeking behaviour, as shown by the MS rats, could be a predisposing factor for substance abuse and addiction. Thus, our study highlights the crucial and differential impact of early life challenges on behaviour during adulthood and suggests that the positive aspects could be an asset that may be utilized to suppress the negative effects of early life stress in adulthood.

Indexed as

Interpersonal RelationsMaternal DeprivationAnimalsAnimals, NewbornAnxietyAttentionFemaleMalePregnancyRatsRats, WistarSocial BehaviorSpatial LearningStress, PsychologicalTime Factors5-Choice serial reaction time task (5CSRTT)AnxietyCognitive flexibilityLearning and memoryMaternal separation stress (MS)PerseverationSustained attention

Identifiers

PMID31154461
OpenAlexW2947332382

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.