Evidence map›Paper›PMID 31154070›Full record

ArticleReproductive toxicology (Elmsford, N.Y.)2019

Marijuana-derived cannabinoids inhibit uterine endometrial stromal cell decidualization and compromise trophoblast-endometrium cross-talk.

Naveen K Neradugomma, Kaitlyn Drafton, Gil G Mor, Qingcheng Mao

Open access · greenAbstract read
In one paragraph

Article in Reproductive toxicology (Elmsford, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Cannabis and Cannabinoids in Reproduction and Fertility: Where We Stand.Reproductive sciences (Thousand Oaks, Calif.) · 2022
    Review
  9. Article
  10. Metabolic Consequences of Gestational Cannabinoid Exposure.International journal of molecular sciences · 2021
    Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Naveen K NeradugommaDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USA. Electronic address: naveennk@uw.edu.
Kaitlyn DraftonDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USA.
Gil G MorDivision of Reproductive Sciences, School of Medicine, Yale University, New Haven, CT 06520, USA.
Qingcheng MaoDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USA. Electronic address: qmao@uw.edu.
University of Washington · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Understanding Fetal Exposure to Cannabinoids Through In Vitro and In Vivo StudiesP01DA032507 · NIDA · UNIVERSITY OF WASHINGTON · PI UNADKAT, JASHVANT D · 2013 to 2023
$12.4M
NCATS NIH HHS UL1 TR001863NIDA NIH HHS P01 DA032507
6 · The paper itself

Abstract

Marijuana (cannabis) use by pregnant women in the United States is increasing and there is a dire need to understand the beneficial or harmful effects of cannabis during pregnancy. Uterine endometrial stromal cells are fibroblast-like cells that differentiate into secretory cells, a process called decidualization, to create a microenvironment conducive for placenta formation and early embryonic growth. In this study, using model human cell lines, we for the first time demonstrate that Δ

Indexed as

CannabinoidsCannabisCell LineEndometriumFemaleHumansReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Stromal CellsTrophoblastsCannabinoidsCNR1 protein, humanCNR2 protein, humanReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2CannabinoidsCBDDeciduaDecidualizationEmbryoEndometrial stromal cellsFertilityMarijuanaMedicineReproductionTHCTrophoblast-endometrium cross-talk models

Identifiers

PMID31154070
PMCPMC6613995
OpenAlexW2947199176

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.