Evidence map›Paper›PMID 31154022›Full record

ArticleGastroenterology2019

Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.

Yuhong Luo, Cen Xie, Chad N Brocker, Jie Fan, Xuan Wu, Lijin Feng, Qiong Wang, Jie Zhao, Dasheng Lu, Mayank Tandon and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 149 citations in OpenAlex.

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42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Yuhong LuoLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Cen XieLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Chad N BrockerLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Jie FanDepartment of Pathology, Huashan Hospital, Fudan University, Shanghai, China.
Xuan WuCentral Laboratory and Department of Laboratory Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China; Department of Laboratory Medicine, Shanghai Skin Disease Hospital, Tongji University, Shanghai, China.
Lijin FengDepartment of Pathology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Qiong WangLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Jie ZhaoLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Dasheng LuLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Mayank TandonCCR Collaborative Bioinformatics Resource, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, Maryland.
Maggie CamCCR Collaborative Bioinformatics Resource, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Kristopher W KrauszLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Weiwei LiuCentral Laboratory and Department of Laboratory Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China; Department of Laboratory Medicine, Shanghai Skin Disease Hospital, Tongji University, Shanghai, China. Electronic address: hsvivian@tongji.edu.cn.
Frank J GonzalezLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Electronic address: gonzalef@mail.nih.gov.
National Institutes of Health · USTongji University · CNFudan University · CN

Funding

Xenobiotic receptorsZIABC005562 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK J · 2009 to 2025
$26.9M
Intramural NIH HHS ZIA BC005562
6 · The paper itself

Abstract

BACKGROUND &

aimsMany genetic and environmental factors, including family history, dietary fat, and inflammation, increase risk for colon cancer development. Peroxisome proliferator-activated receptor alpha (PPARα) is a nuclear receptor that regulates systemic lipid homeostasis. We explored the role of intestinal PPARα in colon carcinogenesis.

methodsColon cancer was induced in mice with intestine-specific disruption of Ppara (Ppara

resultsLevels of Ppara messenger RNA were reduced in colon tumors from mice. Ppara

conclusionsLoss of PPARα from the intestine promotes colon carcinogenesis by increasing DNMT1-mediated methylation of P21 and PRMT6-mediated methylation of p27 in mice. Human colorectal tumors have lower levels of PPARA messenger RNA and protein than nontumor tissues. Agents that activate PPARα might be developed for chemoprevention or treatment of colon cancer.

Indexed as

DNA MethylationAdenocarcinomaAnimalsAnticarcinogenic AgentsCase-Control StudiesCell Cycle ProteinsCell Transformation, NeoplasticColonColonic NeoplasmsDatabases, GeneticDisease Models, AnimalDNA (Cytosine-5-)-Methyltransferase 1FenofibrateGene Expression Regulation, NeoplasticHumansMice, 129 StrainAnticarcinogenic AgentsCell Cycle ProteinsDNA (Cytosine-5-)-Methyltransferase 1DNMT1 protein, humanDnmt1 protein, mouseFenofibrateNuclear ProteinsPPAR alphaPPARA protein, humanPpara protein, mousePRMT6 protein, humanPRMT6 protein, mouseProtein-Arginine N-MethyltransferasesEpigeneticMouse ModelTranscriptional Regulation

Identifiers

PMID31154022
PMCPMC7388731
OpenAlexW2946992647

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.